University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

On the origin of equatorial Atlantic biases in coupled general circulation models

Abstract: Many coupled ocean–atmosphere general circulation models (GCMs) suffer serious biases in the tropical Atlantic including a southward shift of the intertropical convergence zone (ITCZ) in the annual mean, a westerly bias in equatorial surface winds, and a failure to reproduce the eastern equatorial cold tongue in boreal summer. The present study examines an ensemble of coupled GCMs and their uncoupled atmospheric component to identify common sources of error. It is found that the westerly wind bias also exists in the atmospheric GCMs forced with observed sea surface temperature, but only in boreal spring. During this time sea-level pressure is anomalously high (low) in the western (eastern) equatorial Atlantic, which appears to be related to deficient (excessive) precipitation over tropical South America (Africa). In coupled simulations, this westerly bias leads to a deepening of the thermocline in the east, which prevents the equatorial cold tongue from developing in boreal summer. Thus reducing atmospheric model errors during boreal spring may lead to improved coupled simulations of tropical Atlantic climate.

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs.

Abstract: BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms. To answer the question if different germline BAP1 mutations may predispose to a single syndrome with a wide phenotypic range or to distinct syndromes, we investigated the presence of melanocytic tumors in two unrelated families (L and W) with germline BAP1 mutations and increased risk of malignant mesothelioma. Suspicious cutaneous lesions were clinically and pathologically characterized and compared to those present in other families carrying BAP1 mutations. We then conducted a meta-analysis of all the studies reporting BAP1-mutated families to survey cancer risk related to the germline BAP1 mutation (means were compared using t-test and proportions were compared with Pearson χ2 test or two-tailed Fisher’s exact test). Melanocytic tumors: of the five members of the L family studied, four (80%) carried a germline BAP1 mutation (p.Gln684*) and also presented one or more atypical melanocytic tumors; of the seven members of W family studied, all carried a germline BAP1 mutation (p.Pro147fs*48) and four of them (57%) presented one or more atypical melanocytic tumors, that we propose to call “melanocytic BAP1-mutated atypical intradermal tumors” (MBAITs). Meta-analysis: 118 individuals from seven unrelated families were selected and divided into a BAP1-mutated cohort and a BAP1-non-mutated cohort. Malignant mesothelioma, uveal melanoma, cutaneous melanoma, and MBAITs prevalence was significantly higher in the BAP1-mutated cohort (p ≤ 0.001). Germline BAP1 mutations are associated with a novel cancer syndrome characterized by malignant mesothelioma, uveal melanoma, cutaneous melanoma and MBAITs, and possibly by other cancers. MBAITs provide physicians with a marker to identify individuals who may carry germline BAP1 mutations and thus are at high risk of developing associated cancers.

Anthropogenic carbon release rate unprecedented during the past 66 million years

Abstract: Carbon release rates during the Palaeocene–Eocene Thermal Maximum are difficult to constrain. Comparing relative rates of carbon cycle and climate change at the event’s onset suggests emissions were much slower than anthropogenic emissions.