Institution
University of Hawaii at Manoa
Education•Honolulu, Hawaii, United States•
About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.
Papers published on a yearly basis
Papers
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Jeroen R. Huyghe1, Stephanie A. Bien1, Tabitha A. Harrison1, Hyun Min Kang2 +221 more•Institutions (68)
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.
Abstract: To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.
324 citations
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TL;DR: Photometric and spectroscopic observations of SN1993J ten years after the explosion detect the unambiguous signature of a massive star: the binary companion to the progenitor.
Abstract: The massive star that underwent a collapse of its core to produce supernova (SN)1993J was subsequently identified as a non-variable red supergiant star in images of the galaxy M81 taken before explosion1,2. It showed an excess in ultraviolet and B-band colours, suggesting either the presence of a hot, massive companion star or that it was embedded in an unresolved young stellar association1. The spectra of SN1993J underwent a remarkable transformation from the signature of a hydrogen-rich type II supernova to one of a helium-rich (hydrogen-deficient) type Ib3,4. The spectral and photometric peculiarities were best explained by models in which the 13–20 solar mass supergiant had lost almost its entire hydrogen envelope to a close binary companion5,6,7, producing a ‘type IIb’ supernova, but the hypothetical massive companion stars for this class of supernovae have so far eluded discovery. Here we report photometric and spectroscopic observations of SN1993J ten years after the explosion. At the position of the fading supernova we detect the unambiguous signature of a massive star: the binary companion to the progenitor.
323 citations
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TL;DR: Simulation analysis is employed to show that, even in the absence of the capital dilution effect, low fertility leads to higher per capita consumption through human capital accumulation, given plausible model parameters.
Abstract: Do low fertility and population aging lead to economic decline if couples have fewer children, but invest more in each child? By addressing this question, this article extends previous work in which the authors show that population aging leads to an increased demand for wealth that can, under some conditions, lead to increased capital per worker and higher per capita consumption. This article is based on an overlapping generations (OLG) model which highlights the quantity–quality tradeoff and the links between human capital investment and economic growth. It incorporates new national level estimates of human capital investment produced by the National Transfer Accounts project. Simulation analysis is employed to show that, even in the absence of the capital dilution effect, low fertility leads to higher per capita consumption through human capital accumulation, given plausible model parameters.
323 citations
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National Oceanography Centre, Southampton1, Texas A&M University2, Tohoku University3, University of Bristol4, Ocean Drilling Program5, University of California, Davis6, University of Leicester7, Stockholm University8, University of Paris9, University College London10, University of New Orleans11, University of Florida12, Goethe University Frankfurt13, University of California, Santa Cruz14, National Institute of Oceanography, India15, Imperial College London16, University of Birmingham17, Cardiff University18, Lamont–Doherty Earth Observatory19, University of Münster20, Hokkaido University21, Leibniz Institute of Marine Sciences22, Shimane University23, University of Kiel24, Indiana University of Pennsylvania25, Japan Agency for Marine-Earth Science and Technology26, Ibaraki University27, Kōchi University28, Rice University29, University of Michigan30, University of Otago31, University of Louisiana at Lafayette32, University of Rhode Island33, Spanish National Research Council34, University of South Carolina35, Pennsylvania State University36, Utrecht University37, Pusan National University38, Tongji University39, University of Leeds40, University of Bremen41, University of Hawaii at Manoa42, National Institute of Advanced Industrial Science and Technology43
TL;DR: A carbonate accumulation record that covers the past 53 million years from a depth transect in the equatorial Pacific Ocean is presented and large superimposed fluctuations in carbonate compensation depth are found during the middle and late Eocene.
Abstract: Atmospheric carbon dioxide concentrations and climate are regulated on geological timescales by the balance between carbon input from volcanic and metamorphic outgassing and its removal by weathering feedbacks; these feedbacks involve the erosion of silicate rocks and organic-carbon-bearing rocks. The integrated effect of these processes is reflected in the calcium carbonate compensation depth, which is the oceanic depth at which calcium carbonate is dissolved. Here we present a carbonate accumulation record that covers the past 53 million years from a depth transect in the equatorial Pacific Ocean. The carbonate compensation depth tracks long-term ocean cooling, deepening from 3.0-3.5 kilometres during the early Cenozoic (approximately 55 million years ago) to 4.6 kilometres at present, consistent with an overall Cenozoic increase in weathering. We find large superimposed fluctuations in carbonate compensation depth during the middle and late Eocene. Using Earth system models, we identify changes in weathering and the mode of organic-carbon delivery as two key processes to explain these large-scale Eocene fluctuations of the carbonate compensation depth.
322 citations
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TL;DR: Findings support the need to treat symptoms, particularly depression, and to understand clients' perceptions of their environment as strategies to enhance adherence, and expand the concept of adherence in HIV care beyond medication adherence to include following instructions and keeping appointments.
Abstract: This study examined the relationships between the five dimensions of the Wilson and Cleary model of health-related quality of life and three self-reported adherence measures in persons living with HIV using a descriptive survey design. Data collection occurred in seven cities across the United States, including university-based AIDS clinics, private practices, public and for-profit hospitals, residential and day-care facilities, community-based organizations, and home care. The three dependent adherence measures studied were "medication nonadherence," "follows provider advice," and "missed appointments." The sample included 420 persons living with HIV disease with a mean age of 39 years of which 20% were women and 51% were white; subjects had a mean CD4 count of 321 mm3. HIV-positive clients with higher symptom scores, particularly depression, were more likely to be nonadherent to medication, not to follow provider advice, and to miss appointments. Participants who reported having a meaningful life, feeli...
322 citations
Authors
Showing all 13867 results
Name | H-index | Papers | Citations |
---|---|---|---|
Pulickel M. Ajayan | 176 | 1223 | 136241 |
Steven N. Blair | 165 | 879 | 132929 |
Qiang Zhang | 161 | 1137 | 100950 |
Jack M. Guralnik | 148 | 453 | 83701 |
Thomas J. Smith | 140 | 1775 | 113919 |
James A. Richardson | 136 | 363 | 75778 |
Donna Neuberg | 135 | 810 | 72653 |
Jian Zhou | 128 | 3007 | 91402 |
Eric F. Bell | 128 | 631 | 72542 |
Jorge Luis Rodriguez | 128 | 834 | 73567 |
Bin Wang | 126 | 2226 | 74364 |
Nicholas J. Schork | 125 | 587 | 62131 |
Matthew Jones | 125 | 1161 | 96909 |
Anthony F. Jorm | 124 | 798 | 67120 |
Adam G. Riess | 118 | 363 | 117310 |