University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

Abstract: Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian cancer (cases) and 2,354 controls, with follow up of 21,955 SNPs in 4,162 cases and 4,810 controls, leading to the identification of a confirmed susceptibility locus at 9p22 (in BNC2). Here, we report on nine additional candidate loci (defined as having P ≤ 10⁻⁴) identified after stratifying cases by histology, which we genotyped in an additional 4,353 cases and 6,021 controls. We confirmed two new susceptibility loci with P ≤ 5 × 10⁻⁸ (8q24, P = 8.0 × 10⁻¹⁵ and 2q31, P = 3.8 × 10⁻¹⁴) and identified two additional loci that approached genome-wide significance (3q25, P = 7.1 × 10⁻⁸ and 17q21, P = 1.4 × 10⁻⁷). The associations of these loci with serous ovarian cancer were generally stronger than with other cancer subtypes. Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.

Can Luzon Strait Transport Play a Role in Conveying the Impact of ENSO to the South China Sea

Abstract: The Luzon Strait transport (LST) from the Pacific into the South China Sea (SCS) is examined using results from a high-resolution ocean general circulation model. The LST from the model has a mean value of 2.4 Sv (Sv ( 106 m3 s 21) and reaches its seasonal maximum (6.1 Sv westward) in winter and seasonal minimum (0.9 Sv eastward) in summer. Both the annual mean and seasonal variation of LST compare favorably with earlier observations. On an interannual time scale, LST tends to be higher during El Nino years and lower during La Nina years, with its maximum (minimum) leading the mature phase of El Nino (La Nina) by 1 month. The interannual variation of LST appears to be oppositely phased with the Kuroshio transport east of Luzon, indicating a possible nonlinear hysteresis of the Kuroshio as a driving mechanism of LST. For the annual average, water leaving the SCS in the south is of higher temperature than that with LST, thus producing a cooling advection in the upper 405 m equivalent to a surface heat flux of 2 19 Wm 22. Most of this cooling advection is balanced by the atmospheric heating (17 W m22). From late spring to early fall, surface heat flux is the primary heating process; only a small part of the heat content change can be explained by heat advection. But, in winter, heat advection seems to be the only important process responsible for the cooling in the upper layer of the SCS. The interannual variation of the upper-layer heat content has a strong signature of ENSO, cooling in the development of El Nino and warming in the development of La Nina. An oceanic connection is revealed, in which LST seems to be a key process conveying the impact of the Pacific ENSO into the SCS.