Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
More filters
The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 in High Grade Serous Carcinoma
TL;DR: This study seeks to further validate the prognostic value of fibroblast growth receptor 4 (FGFR4), another candidate gene of the FGF/FGFR axis located in the same amplicon and delineate the role of theFGF1/FG FR4 signaling axis in high grade serous ovarian carcinoma, and test the feasibility of targeting the F GF1/ FGFR4 axis therapeutically.
Journal ArticleDOI
Fibroblast Growth Factor Receptor-4 Expression in Pituitary Adenomas is Associated with Aggressive Tumor Features.
Emre Durcan,Fatma Ela Keskin,Hande Mefkure Ozkaya,Sabri Sirolu,Serdar Sahin,Ozge Polat Korkmaz,Nurperi Gazioglu,Necmettin Tanriover,Nil Comunoglu,Buge Oz,Osman Kizilkilic,Pinar Kadioglu +11 more
TL;DR: In this paper, the relationship of FGFR-4 expression with radiologic, pathologic, and clinical parameters in pituitary adenomas was investigated using a semi-quantitative histologic score (H-score).
Journal ArticleDOI
Fibroblast growth factor receptor 2 gene (FGFR2) rs2981582T/C polymorphism and susceptibility to breast cancer in Saudi women.
Rawya Ibrahim Al-Raddadi,Razan Jamaan Al-amri,Weam Talal Yehya Shebli,Emad Ibrahim Yagoub Fallatah,Ahmed Safar Alhujaily,Hiba S. Mohamed,Hiba S. Mohamed,Mohammad Kdaimes H. Alotibi +7 more
TL;DR: An association of FGFR2 rs2981582T/C with breast cancer in Saudi women was found and a significant difference was found in genotypes and alleles distribution in ER+, PR- and HER2 between breast cancer cases and controls.
Journal ArticleDOI
Miscellaneous treatments, II: niacin and heparin: unapproved uses, dosages, or indications.
TL;DR: Although the specific agent (niacin) that cured the disease was discovered by Elvehjem and Fouts in 1937, Joseph Goldberger will always be remembered as the “unsung hero of American clinical epidemiology” who solved the secret of the malady.
References
More filters
Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Journal ArticleDOI
Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
Journal ArticleDOI
Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.