Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Herman Jan Pel,Johannes H. de Winde,Johannes H. de Winde,David B. Archer,Paul S. Dyer,Gerald Hofmann,Peter J. Schaap,Geoffrey Turner,Ronald P. de Vries,Richard Albang,Kaj Albermann,Mikael Rørdam Andersen,Jannick Dyrløv Bendtsen,Jacques A.E. Benen,Marco A. van den Berg,Stefaan Breestraat,Mark X. Caddick,Roland Contreras,Michael Cornell,Pedro M. Coutinho,Etienne Danchin,Alfons J. M. Debets,Peter J. T. Dekker,Piet W.M. van Dijck,Alard Van Dijk,Lubbert Dijkhuizen,Arnold J. M. Driessen,Christophe d'Enfert,Steven Geysens,Coenie Goosen,Gert S.P. Groot,Piet W. J. de Groot,Thomas Guillemette,Bernard Henrissat,Marga Herweijer,Johannes Petrus Theodorus Wilhelmus Van Den Hombergh,Cees A. M. J. J. van den Hondel,René T. J. M. van der Heijden,Rachel M. van der Kaaij,Frans M. Klis,Harrie J. Kools,Christian P. Kubicek,Patricia Ann van Kuyk,Jürgen Lauber,Xin Lu,Marc J. E. C. van der Maarel,Rogier Meulenberg,Hildegard Henna Menke,Martin Mortimer,Jens Nielsen,Stephen G. Oliver,Maurien M.A. Olsthoorn,K. Pal,K. Pal,Noël Nicolaas Maria Elisabeth Van Peij,Arthur F. J. Ram,Ursula Rinas,Johannes Andries Roubos,Cornelis Maria Jacobus Sagt,Monika Schmoll,Jibin Sun,David W. Ussery,János Varga,Wouter Vervecken,Peter J.J. Van De Vondervoort,Holger Wedler,Han A. B. Wösten,An-Ping Zeng,Albert J. J. van Ooyen,Jaap Visser,Hein Stam +70 more
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TLDR
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid, and the sequenced genome revealed a large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors.Abstract:
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.read more
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Priorities for nucleotide trace, sequence and annotation data capture at the Ensembl Trace Archive and the EMBL Nucleotide Sequence Database
Guy Cochrane,Ruth Akhtar,Philippe Aldebert,Nicola Althorpe,Alastair Baldwin,Kirsty Bates,Sumit Bhattacharyya,James K. Bonfield,Lawrence Bower,Paul Browne,Matias Castro,Tony Cox,Fehmi Demiralp,Ruth Y. Eberhardt,Nadeem Faruque,Gemma Hoad,Mikyung Jang,Tamara Kulikova,Alberto Labarga,Rasko Leinonen,Steven Leonard,Quan Lin,Rodrigo Lopez,Dariusz Lorenc,Hamish McWilliam,Gaurab Mukherjee,Francesco Nardone,Sheila Plaister,Stephen J. Robinson,Siamak Sobhany,Robert Vaughan,Dan Wu,Weimin Zhu,Rolf Apweiler,Tim Hubbard,Ewan Birney +35 more
TL;DR: In the face of increasing requirements for nucleotide trace, sequence and annotation data archiving, data capture priority decisions have been taken at the European Nucleotide Archive.
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A xyloglucan-specific family 12 glycosyl hydrolase from Aspergillus niger: recombinant expression, purification and characterization.
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Hydrophobins from Aspergillus species cannot be clearly divided into two classes
Britt Guillaume Jensen,Mikael Rørdam Andersen,Mona Højgaard Pedersen,Jens Christian Frisvad,Ib Søndergaard +4 more
TL;DR: This is the first report of an Aspergillus species with the potential to express both class I and class II hydrophobins, which are involved in the attachment of hyphae to hydrophobic structures, the formation of aerial structures and appear to be involved in pathogenicity.
Book ChapterDOI
Genetics, Genetic Manipulation, and Approaches to Strain Improvement of Filamentous Fungi
TL;DR: This chapter discusses some of the concepts and tools that have proven particularly powerful for optimizing industrial fungal strains, and focuses on alternative strain improvement approaches, and summarizes some rules of thumb that are found to be critical for successful cultivation of filamentous fungi in a bioreactor.
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Recent Developments in Using Advanced Sequencing Technologies for the Genomic Studies of Lignin and Cellulose Degrading Microorganisms
TL;DR: In this review, recent advancements deployed for finding and understanding the lignocellulose degradation by microorganisms are focused on.
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