Circulating platelets as liquid biopsy sources for cancer detection.
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TLDR
The usability of platelets as a liquid biopsy for the detection of cancer is addressed, describing several studies that support the use of platelet biomarkers in cancer diagnostics and discussing what is still lacking for their implementation into the clinic.About:
This article is published in Molecular Oncology.The article was published on 2021-06-01 and is currently open access. It has received 28 citations till now. The article focuses on the topics: Liquid biopsy & Cancer biomarkers.read more
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The potential of liquid biopsy in the management of cancer patients.
TL;DR: In this article , the benefits and main clinical applications of CTC and ctDNA analysis in solid tumors are summarized in the field of liquid biopsy and their recent findings in the literature are summarized.
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An integrated electrochemical POCT platform for ultrasensitive circRNA detection towards hepatocellular carcinoma diagnosis.
Bin Zhang,Mingyu Chen,Jiasheng Cao,Yitao Liang,Tingting Tu,Jiahao Hu,Tianyu Li,Yu Cai,Shijie Li,Boqiang Liu,Junjie Xu,Bo Liang,Xuesong Ye,Xiujun Cai +13 more
TL;DR: In this paper, a fully integrated electrochemical POCT platform for circRNA detection based on Au nanoflowers (AuNFs)/peptide nucleic acid (PNA) modified carbon-fiber microelectrode (CFME) was presented.
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Inflammation and Cancer: From the Development of Personalized Indicators to Novel Therapeutic Strategies
Patrizia Ballerini,Annalisa Contursi,Annalisa Bruno,Matteo Mucci,Stefania Tacconelli,Paola Patrignani +5 more
TL;DR: In this article , a low-dose Aspirin, an anti-platelet agent, reduces CRC and hepatocellular carcinoma (HCC) incidence and mortality.
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Single extracellular vesicle analysis for early cancer detection.
TL;DR: Extracellular vesicles (EVs) are actively shed into the circulation from both cancer and host cells as mentioned in this paper and are emerging as one of the diagnostic frontrunners for early cancer detection, disease monitoring, and treatment evaluation.
Journal ArticleDOI
Identification of seven tumor-educated platelets RNAs for cancer diagnosis.
TL;DR: In this paper, the role of TEPs DEGs in cancer diagnosis was evaluated using qRT-PCR to identify diagnostic TEP DEGs genes involved in carcinogenesis, including RSL24D1, IFI27, CRYM, HBD, COL6A3, LAMB2 and IFITM3.
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TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
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Cancer drug resistance: an evolving paradigm
TL;DR: There are now unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive biomarkers to enable patient stratification.
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Liquid biopsies come of age: towards implementation of circulating tumour DNA
Jonathan C. M. Wan,Charles E. Massie,Javier Garcia-Corbacho,Florent Mouliere,James D. Brenton,Carlos Caldas,Simon Pacey,Richard D. Baird,Nitzan Rosenfeld +8 more
TL;DR: The field is now in an exciting transitional period in which ctDNA analysis is beginning to be applied clinically, although there is still much to learn about the biology of cell-free DNA.
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