Fibroblast growth factors, their receptors and signaling.
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Dissertation
The secreted serine protease xHtrA1 is a positive feedback regulator of long-range FGF signaling.
TL;DR: These findings suggest that xHtrA1 may act as a positive feedback regulator of FGF signals that through proteolytic cleavage of proteoglycans allows long-range FGF signaling in the extracellular space.
Journal ArticleDOI
Transcriptome Sequencing to Identify Important Genes and lncRNAs Regulating Abdominal Fat Deposition in Ducks
Chunyan Yang,Zhixiu Wang,Qianqian Song,Bingqiang Dong,Yulin Bi,Hao Bai,Yang Jiang,Guobin Chang,Guo-Rong Chen +8 more
TL;DR: Transcriptome sequencing of the abdominal adipose tissue of ducks with high and low abdominal fat rate by RNA sequencing explored the key regulatory genes and lncRNAs related to abdominal fat deposition, indicating that these lnc RNAs play an important role in abdominalFat deposition.
Journal Article
Kynurenine Inhibits Fibroblast Growth Factor-2 Mediated Expression of Crystallins and MIP26 in Lens Epithelial Cells
TL;DR: This article showed that exogenous kynurenine (KYN) produced from the overexpression of indoleamine 2,3-dioxygenase (IDO) causes defects in the differentiation of fiber cells, induces fiber cell apoptosis and cataract formation in the mouse lens, and leads to cell cycle arrest in cultured mouse lens epithelial cells (mLEC).
Book ChapterDOI
Bioactive Oxidised Products of Omega-6 and Omega-3, Excess Oxidative Stress, Oxidised Dietary Intake and Antioxidant Nutrient Deficiencies, in the Context of a Modern Diet
TL;DR: Oxidised and elongated LA products—key regulators in important biological mechanisms and systems including; inflammation; immune function and defence; hormone production; pheromones; placental and foetal development; parturition; energy regulation; and fat deposition,—and ultimately control reproductive capacity.
Patent
6-carboaryl-oxy-pyrazin-2-yl-carboaryl-amines and compositions comprising said compounds
Caroline Joy Springer,Ion Niculescu-Duvaz,Esteban Roman Vela,Adrian Liam Gill,Richard D. Taylor,Richard Malcolm Marais +5 more
Abstract: The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is independently —N═; R P3 is independently a group of the formula -J 1 -L 1 -Z; -J 1 L 1 -Z is independently —NH—Z; Z is independently C 6-14 carboaryl and is independently unsubstituted or substituted; R P2 is independently —H; R P5 is independently a group of the formula —W—Y; W is independently —O—; Y is independently C 6-14 carboaryl and is independently unsubstituted or substituted; and R P6 is independently —H. The present invention also pertains to pharmaceutical compositions comprising such compounds.
References
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Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Journal ArticleDOI
Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
Journal ArticleDOI
Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.