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Journal ArticleDOI

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders.

Phil Lee, +2 more
- 01 Jan 2021 - 
- Vol. 89, Iss: 1, pp 20-31
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TLDR
Underlying mechanisms of observed pleiotropy are examined, including genetic effects on neurodevelopment, diverse actions of regulatory elements, mediated effects, and spurious associations of genomic variation with multiple phenotypes.
About: 
This article is published in Biological Psychiatry.The article was published on 2021-01-01. It has received 64 citations till now. The article focuses on the topics: Genetic architecture & Pleiotropy (drugs).

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Citations
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Genetic Risk for Autism Spectrum Disorders and Neuropsychiatric Variation in the General Population

Elise B. Robinson, +15 more
TL;DR: The authors found genome-wide genetic links between autism spectrum disorders and typical variation in social behavior and adaptive functioning through LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder.

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Christian R. Marshall, +262 more
TL;DR: A centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls and Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
Journal ArticleDOI

Cross-trait assortative mating is widespread and inflates genetic correlation estimates

Richard Border, +11 more
- 23 Mar 2022 - 
TL;DR: The introduction of cross-trait assortative mating (xAM) as an alternative explanation for observed genetic correlations is introduced and results demonstrate that previous reports have likely overestimated the true genetic similarity between many phenotypes.
Journal ArticleDOI

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation.

Guy F.L. Hindley, +16 more
- 07 Sep 2022 - 
TL;DR: In this article , the authors applied the bivariate causal mixture model (MiXeR) to summary statistics for four mental disorders, four related mental traits, and height from genome-wide association studies (Ns ranged from 53,293 to 766,345).
Journal Article

Enhancer control of transcriptional bursting

Takashi Fukaya, +2 more
- 08 Nov 2016 - 
TL;DR: In this article, the authors examined transcriptional bursting in living Drosophila embryos and found that different developmental enhancers positioned downstream of synthetic reporter genes produce transcriptional bursts with similar amplitudes and duration but generate very different bursting frequencies.
References
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Journal ArticleDOI

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019.

Annalisa Buniello, +24 more
- 08 Jan 2019 - 
TL;DR: Improved data access is improved with the release of a new RESTful API to support high-throughput programmatic access, an improved web interface and a new summary statistics database.
Journal ArticleDOI

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

Jordan W. Smoller, +33 more
- 20 Apr 2013 - 
TL;DR: The findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset, and variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology.
Journal ArticleDOI

Mendelian randomization: using genes as instruments for making causal inferences in epidemiology.

Debbie A Lawlor, +4 more
- 15 Apr 2008 - 
TL;DR: The use of germline genetic variants that proxy for environmentally modifiable exposures as instruments for these exposures is one form of IV analysis that can be implemented within observational epidemiological studies and can be considered as analogous to randomized controlled trials.
Journal ArticleDOI

An Expanded View of Complex Traits: From Polygenic to Omnigenic

Evan A. Boyle, +3 more
- 15 Jun 2017 - 
TL;DR: It is proposed that gene regulatory networks are sufficiently interconnected such that all genes expressed in disease-relevant cells are liable to affect the functions of core disease-related genes and that most heritability can be explained by effects on genes outside core pathways.
Journal ArticleDOI

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Naomi R. Wray, +262 more
- 26 Apr 2018 - 
TL;DR: A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil Lee, +606 more
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The implications of the shared genetics of psychiatric disorders

Michael Conlon O'Donovan, +1 more
- 26 Oct 2016 - 

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

Phil Lee, +58 more
- 26 Jan 2019 - 

Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective.

Frank R. Wendt, +4 more

Genetics and genomics of behavioral and psychiatric disorders

Ken Inoue, +1 more
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