J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Analysis of protein-coding genetic variation in 60,706 humans
Monkol Lek,Konrad J. Karczewski,Konrad J. Karczewski,Eric Vallabh Minikel,Eric Vallabh Minikel,Kaitlin E. Samocha,Eric Banks,Timothy Fennell,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,James S. Ware,Andrew J. Hill,Andrew J. Hill,Andrew J. Hill,Beryl B. Cummings,Beryl B. Cummings,Taru Tukiainen,Taru Tukiainen,Daniel P. Birnbaum,Jack A. Kosmicki,Laramie E. Duncan,Laramie E. Duncan,Karol Estrada,Karol Estrada,Fengmei Zhao,Fengmei Zhao,James Zou,Emma Pierce-Hoffman,Emma Pierce-Hoffman,Joanne Berghout,David Neil Cooper,Nicole A. Deflaux,Mark A. DePristo,Ron Do,Jason Flannick,Jason Flannick,Menachem Fromer,Laura D. Gauthier,Jackie Goldstein,Jackie Goldstein,Namrata Gupta,Daniel P. Howrigan,Daniel P. Howrigan,Adam Kiezun,Mitja I. Kurki,Mitja I. Kurki,Ami Levy Moonshine,Pradeep Natarajan,Lorena Orozco,Gina M. Peloso,Gina M. Peloso,Ryan Poplin,Manuel A. Rivas,Valentin Ruano-Rubio,Samuel A. Rose,Douglas M. Ruderfer,Khalid Shakir,Peter D. Stenson,Christine Stevens,Brett Thomas,Brett Thomas,Grace Tiao,María Teresa Tusié-Luna,Ben Weisburd,Hong-Hee Won,Dongmei Yu,David Altshuler,David Altshuler,Diego Ardissino,Michael Boehnke,John Danesh,Stacey Donnelly,Roberto Elosua,Jose C. Florez,Jose C. Florez,Stacey Gabriel,Gad Getz,Gad Getz,Stephen J. Glatt,Christina M. Hultman,Sekar Kathiresan,Markku Laakso,Steven A. McCarroll,Steven A. McCarroll,Mark I. McCarthy,Mark I. McCarthy,Dermot P.B. McGovern,Ruth McPherson,Benjamin M. Neale,Benjamin M. Neale,Aarno Palotie,Shaun Purcell,Danish Saleheen,Jeremiah M. Scharf,Pamela Sklar,Patrick F. Sullivan,Patrick F. Sullivan,Jaakko Tuomilehto,Ming T. Tsuang,Hugh Watkins,Hugh Watkins,James G. Wilson,Mark J. Daly,Mark J. Daly,Daniel G. MacArthur,Daniel G. MacArthur +106 more
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals of diverse ancestries generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
Journal ArticleDOI
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena,Benjamin F. Voight,Valeriya Lyssenko,Noël P. Burtt,Paul I.W. de Bakker,Hong Chen,Jeffrey J. Roix,Sekar Kathiresan,Joel N. Hirschhorn,Mark J. Daly,Thomas E. Hughes,Leif Groop,David Altshuler,Peter Almgren,Jose C. Florez,Joanne M. Meyer,Kristin Ardlie,Kristina Bengtsson Boström,Bo Isomaa,Guillaume Lettre,Ulf Lindblad,Helen N. Lyon,Olle Melander,Christopher Newton-Cheh,Peter Nilsson,Marju Orho-Melander,Lennart Råstam,Elizabeth K. Speliotes,Marja-Riitta Taskinen,Tiinamaija Tuomi,Candace Guiducci,Anna Berglund,Joyce Carlson,Lauren Gianniny,Rachel Hackett,Liselotte Hall,Johan Holmkvist,Esa Laurila,Marketa Sjögren,Maria Sterner,Aarti Surti,Margareta Svensson,Malin Svensson,Ryan Tewhey,Brendan Blumenstiel,Melissa Parkin,Matthew DeFelice,Rachel Barry,Wendy Brodeur,Jody Camarata,Nancy Chia,Mary Fava,John G. Gibbons,Bob Handsaker,Claire M. Healy,Kieu Nguyen,Casey Gates,Carrie Sougnez,Diane Gage,Marcia M. Nizzari,Stacey Gabriel,Gung-Wei Chirn,Qicheng Ma,Hemang Parikh,Delwood Richardson,Darrell O. Ricke,Shaun Purcell +66 more
TL;DR: The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Journal ArticleDOI
Metabolite profiles and the risk of developing diabetes
Thomas J. Wang,Martin G. Larson,Martin G. Larson,Ramachandran S. Vasan,Ramachandran S. Vasan,Susan Cheng,Susan Cheng,Susan Cheng,Eugene P. Rhee,Eugene P. Rhee,Elizabeth L. McCabe,Elizabeth L. McCabe,Gregory D. Lewis,Gregory D. Lewis,Caroline S. Fox,Caroline S. Fox,Paul F. Jacques,Céline Fernandez,Christopher J. O'Donnell,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen A Carr,Vamsi K. Mootha,Vamsi K. Mootha,Jose C. Florez,Jose C. Florez,Amanda Souza,Olle Melander,Clary B. Clish,Robert E. Gerszten,Robert E. Gerszten +30 more
TL;DR: Findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.
Journal ArticleDOI
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis,Josée Dupuis,Claudia Langenberg,Inga Prokopenko,Richa Saxena,Richa Saxena,Nicole Soranzo,Nicole Soranzo,Anne U. Jackson,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Anna L. Gloyn,Cecilia M. Lindgren,Reedik Mägi,Andrew P. Morris,Joshua C. Randall,Toby Johnson,Toby Johnson,Paul Elliott,Paul Elliott,Denis Rybin,Gudmar Thorleifsson,Valgerdur Steinthorsdottir,Peter Henneman,Harald Grallert,Abbas Dehghan,Jouke JanHottenga,Christopher S. Franklin,Pau Navarro,Kijoung Song,Anuj Goel,John R. B. Perry,Josephine M. Egan,Taina K. Lajunen,Niels Grarup,Thomas Sparsø,Alex S. F. Doney,Benjamin F. Voight,Benjamin F. Voight,Heather M. Stringham,Man Li,Stavroula Kanoni,Peter Shrader,Christine Cavalcanti-Proença,Meena Kumari,Lu Qi,Nicholas J. Timpson,Christian Gieger,Carina Zabena,Ghislain Rocheleau,Erik Ingelsson,Erik Ingelsson,Ping An,Jeffrey R. O'Connell,Jian'an Luan,Amanda F. Elliott,Amanda F. Elliott,Steven A. McCarroll,Steven A. McCarroll,Felicity Payne,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Kristin Ardlie,Yavuz Ariyurek,Beverley Balkau,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Rafn Benediktsson,Amanda J. Bennett,Sven Bergmann,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Suzannah Bumpstead,Guillaume Charpentier,Yii Der IdaChen,Peter S. Chines,Robert Clarke,Lachlan J. McOin,Mark E. Cooper,Marilyn C. Cornelis,Gabe Crawford,Laura Crisponi,Ian N. M. Day,Eco J. C. de Geus,Jérôme Delplanque,Christian Dina,Michael R. Erdos,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Rune R. Frants,Maria GraziaFranzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,Christopher J. Groves,Scott M. Grundy,Rhian Gwilliam,Ulf Gyllensten,Samy Hadjadj,Göran Hallmans,Naomi Hammond,Xijing Han,Anna LiisaHartikainen,Neelam Hassanali,Caroline Hayward,Simon Heath,Serge Hercberg,Christian Herder,Andrew A. Hicks,David R. Hillman,Aroon D. Hingorani,Albert Hofman,Jennie Hui,Joseph Hung,Joseph Hung,Bo Isomaa,Paul Johnson,Torben Jørgensen,Antti Jula,Marika Kaakinen,Jaakko Kaprio,Jaakko Kaprio,Y. AnteroKesaniemi,Mika Kivimäki,Beatrice Knight,Seppo Koskinen,Peter Kovacs,Kirsten Ohm Kyvik,G. Mark Lathrop,Debbie A Lawlor,Olivier Le Bacquer,Cécile Lecoeur,Yun Li,Valeriya Lyssenko,Robert W. Mahley,Massimo Mangino,Alisa K. Manning,María TeresaMartínez-Larrad,Jarred B. McAteer,Jarred B. McAteer,Laura J. McCulloch,Ruth McPherson,Christa Meisinger,David Melzer,David Meyre,Braxton D. Mitchell,Mario A. Morken,Sutapa Mukherjee,Silvia Naitza,Narisu Narisu,Matt Neville,Ben A. Oostra,Marco Orrù,Ruth E. Pakyz,Colin N. Apalmer,Giuseppe Paolisso,Cristian Pattaro,Daniel S. Pearson,John F. Peden,Nancy L. Pedersen,Markus Perola,Markus Perola,Andreas Pfeiffer,Irene Pichler,Ozren Polasek,Danielle Posthuma,Simon C. Potter,Anneli Pouta,Michael A. Province,Bruce M. Psaty,Bruce M. Psaty,Wolfgang Rathmann,Nigel W. Rayner,Kenneth Rice,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Michael Roden,Olov Rolandsson,Annelli Sandbæk,Manjinder S. Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Laura J. Scott,Udo Seedorf,Stephen J. Sharp,Beverley M. Shields,Gunnar Sigursson,Eric J.G. Sijbrands,Angela Silveira,Laila Simpson,Andrew B. Singleton,Nicholas L. Smith,Nicholas L. Smith,Ulla Sovio,Amy J. Swift,Holly E. Syddall,Ann ChristineSyvänen,Toshiko Tanaka,Toshiko Tanaka,Barbara Thorand,Jean Tichet,Anke Tönjes,Tiinamaija Tuomi,André G. Uitterlinden,Ko Willems van Dijk,Mandy van Hoek,Dhiraj Varma,Sophie Visvikis-Siest,Veronique Vitart,Nicole Vogelzangs,Gerard Waeber,Peter Wagner,Peter Wagner,Andrew Walley,G. BragiWalters,Kim L. Ward,Hugh Watkins,Michael N. Weedon,Sarah H. Wild,Gonneke Willemsen,Jaqueline C. MWitteman,John W. GYarnell,Eleftheria Zeggini,Eleftheria Zeggini,Diana Zelenika,Björn Zethelius,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M. Carola Zillikens,Ingrid B. Borecki,Ruth J. F. Loos,Pierre Meneton,Patrik K. E. Magnusson,David M. Nathan,Gordon H. Williams,Andrew T. Hattersley,Kaisa Silander,Kaisa Silander,Veikko Salomaa,George Davey Smith,Stefan R. Bornstein,Peter Schwarz,Joachim Spranger,Fredrik Karpe,Alan R. Shuldiner,Cyrus Cooper,George Dedoussis,Manuel Serrano-Ríos,Andrew D. Morris,Lars Lind,Lyle J. Palmer,Lyle J. Palmer,Frank B. Hu,Paul W. Franks,Shah Ebrahim,Michael Marmot,W. H. Linda Kao,James S. Pankow,Mike Sampson,Johanna Kuusisto,Markku Laakso,Torben Hansen,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Peter P. Pramstaller,H.-Erich Wichmann,Thomas Illig,Igor Rudan,Igor Rudan,Alan F. Wright,Michael Stumvoll,Harry Campbell,James F. Wilson,Richard N. Bergman,Thomas A. Buchanan,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Jaakko Tuomilehto,Timo T. Valle,David Altshuler,David Altshuler,Jerome I. Rotter,David S. Siscovick,Brenda W.J.H. Penninx,Dorret I. Boomsma,Panos Deloukas,Tim D. Spector,Tim D. Spector,Timothy M. Frayling,Luigi Ferrucci,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Cornelia M. van Duijn,Yurii S. Aulchenko,Antonio Cao,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Marjo Riitta-Järvelin,Marjo Riitta-Järvelin,Dawn M. Waterworth,Peter Vollenweider,Leena Peltonen,Vincent Mooser,Gonçalo R. Abecasis,Nicholas J. Wareham,Robert Sladek,Philippe Froguel,Philippe Froguel,Richard M. Watanabe,James B. Meigs,Leif Groop,Michael Boehnke,Mark I. McCarthy,Jose C. Florez,Jose C. Florez,Inês Barroso +339 more
TL;DR: It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Journal ArticleDOI
A genome-wide association search for type 2 diabetes genes in African Americans.
Nichole D. Palmer,Caitrin W. McDonough,Pamela J. Hicks,B H Roh,M R Wing,S S An,Jessica M. Hester,Jessica N. Cooke,Meredith A. Bostrom,Megan E. Rudock,Matthew E. Talbert,Joshua P. Lewis,Assiamira Ferrara,Lingyi Lu,Julie T. Ziegler,Michèle M. Sale,Jasmin Divers,Daniel Shriner,Adebowale Adeyemo,Charles N. Rotimi,Ng Mcy.,Carl D. Langefeld,Barry I. Freedman,Donald W. Bowden,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Andrew P. Morris,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Cristen J. Willer,Soumya Raychaudhuri,Steven A. McCarroll,Claudia Langenberg,O M Hofmann,Josée Dupuis,Lu Qi,A V Segrè,M. van Hoek,Pau Navarro,Kristin G. Ardlie,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,Kristina Bengtsson Boström,Bert Bravenboer,Suzannah Bumpstead,N P Burtt,Guillaume Charpentier,Peter S. Chines,Marilyn C. Cornelis,David Couper,Gabriel Crawford,Doney Asf.,Kathryn Elliott,A L Elliott,Michael R. Erdos,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Simon J. Griffin,C J Groves,Candace Guiducci,Samy Hadjadj,N Hassanali,C. Herder,Bo Isomaa,Anne U. Jackson,Johnson Prv.,Torben Jørgensen,Kao Whl.,N Klopp,Augustine Kong,Peter Kraft,Johanna Kuusisto,Torsten Lauritzen,Man Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Meghan L. Marré,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,P. M. Nilsson,Katharine R. Owen,Felicity Payne,Perry Jrb.,Petersen A-K.,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Wolfgang Rathmann,N W Rayner,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,B M Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,Amy J. Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,R. M. van Dam,T.W. van Haeften,T van Herpt,J. V. van Vliet-Ostaptchouk,G B Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,Karen L. Mohlke,Andrew D. Morris,Palmer Cna.,Peter P. Pramstaller,Igor Rudan,Eric J.G. Sijbrands,Lincoln D. Stein,Jaakko Tuomilehto,A.G. Uitterlinden,M Walker,Nicholas J. Wareham,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Andrew T. Hattersley,Frank B. Hu,James B. Meigs,James S. Pankow,Oluf Pedersen,Wichmann H-E.,Inês Barroso,Jose C. Florez,Timothy M. Frayling,Leif Groop,R Sladek,Unnur Thorsteinsdottir,James F. Wilson,Thomas Illig,Philippe Froguel,C M van Duijn,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Nicole Soranzo,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Reedik Mägi,Joshua C. Randall,Toby Johnson,Paul Elliott,Denis Rybin,Peter Henneman,Abbas Dehghan,Jouke-Jan Hottenga,Kijoung Song,Anuj Goel,Josephine M. Egan,Taina K. Lajunen,Alex S. F. Doney,Stavroula Kanoni,Christine Cavalcanti-Proença,Meena Kumari,Nicholas J. Timpson,Carina Zabena,Erik Ingelsson,Ping An,Jeffrey R. O'Connell,Jian'an Luan,Amanda F. Elliott,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Yavuz Ariyurek,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Sven Bergmann,Murielle Bochud,Amélie Bonnefond,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Suzannah Bumpstead,Chen Y-Di.,Peter S. Chines,Robert Clarke,Coin Ljm.,Mark E. Cooper,Laura Crisponi,Day Inm.,de Geus Ejc.,Jérôme Delplanque,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,R.R. Frants,MariaGrazia Franzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,Scott M. Grundy,R. Gwilliam,Göran Hallmans,Naomi Hammond,Xijing Han,Hartikainen A-L.,Caroline Hayward,Simon C. Heath,Serge Hercberg,Andrew A. Hicks,David R. Hillman,Aroon D. Hingorani,Jennie Hui,Joseph Hung,A. Jula,Marika Kaakinen,Jaakko Kaprio,Y A Kesaniemi,Mika Kivimäki,Beatrice Knight,Sini Koskinen,Peter Kovacs,Kirsten Ohm Kyvik,G M Lathrop,Debbie A Lawlor,O Le Bacquer,Cécile Lecoeur,Yun Li,Robert W. Mahley,Massimo Mangino,Alisa K. Manning,María Teresa Martínez-Larrad,Jarred B. McAteer,Ruth McPherson,Christine Meisinger,David Melzer,David Meyre,B. D. Mitchell,Sutapa Mukherjee,Silvia Naitza,Matt J. Neville,B.A. Oostra,Marco Orrù,Ruth E. Pakyz,Giuseppe Paolisso,C. Pattaro,D. Pearson,John F. Peden,Nancy L. Pedersen,M. Perola,Pfeiffer Afh.,Irene Pichler,Ozren Polašek,Danielle Posthuma,Simon C. Potter,Anneli Pouta,M. A. Province,Bruce M. Psaty,Kenneth Rice,Samuli Ripatti,F. Rivadeneira,Olov Rolandsson,A. Sandbaek,M. S. Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Udo Seedorf,Stephen J. Sharp,Beverley M. Shields,Sijbrands Ejg.,Angela Silveira,Laila Simpson,Andrew B. Singleton,Nicholas L. Smith,Ulla Sovio,A J Swift,H E Syddall,Syvänen A-C.,Toshiko Tanaka,Anke Tönjes,Andre G. Uitterlinden,K W van Dijk,Dhiraj Varma,Sophie Visvikis-Siest,Veronique Vitart,Nicole Vogelzangs,Gerard Waeber,P J Wagner,Andrew Walley,Kim L. Ward,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,Witteman Jcm.,Yarnell Jwg.,Diana Zelenika,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M. C. Zillikens,Ingrid B. Borecki,Loos Rjf.,Pierre Meneton,Magnusson Pke.,David M. Nathan,Gordon H. Williams,Kaisa Silander,Veikko Salomaa,George Davey Smith,Stefan R. Bornstein,Peter Schwarz,Jochen Spranger,F Karpe,Alan R. Shuldiner,Cyrus Cooper,George Dedoussis,Manuel Serrano-Ríos,Lars Lind,Lyle J. Palmer,Paul W. Franks,Shah Ebrahim,Michael Marmot,Alan F. Wright,Michael Stumvoll,Anders Hamsten,Thomas A. Buchanan,Timo T. Valle,Jerome I. Rotter,David S. Siscovick,Penninx Bwjh.,Dorret I. Boomsma,Panos Deloukas,Tim D. Spector,Luigi Ferrucci,Anyuan Cao,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Jarvelin M-R.,Dawn M. Waterworth,Peter Vollenweider,Leena Peltonen,Vincent Mooser +384 more
TL;DR: It is suggested that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.