Showing papers by "State University of New York System published in 2014"
University of Minnesota1, State University of New York System2, University of Washington3, Laval University4, Malmö University5, Aarhus University6, Aarhus University Hospital7, VU University Amsterdam8, University of Naples Federico II9, University of Michigan10, University of Zurich11, Johns Hopkins University12, University of Copenhagen13, Katholieke Universiteit Leuven14, University of Kentucky15, University of North Carolina at Chapel Hill16, University of Sydney17, University of Minnesota System18, HealthPartners19, University of Auvergne20
TL;DR: The newly recommended evidence-based new DC/TMD protocol is appropriate for use in both clinical and research settings and includes both a valid screener for detecting any pain-related TMD as well as valid diagnostic criteria for differentiating the most common pain- related TMD.
Abstract: Temporomandibular disorders (TMD) are a significant public health problem affecting approximately 5% to 12% of the population.1 TMD is the second most common musculoskeletal condition (after chronic low back pain) resulting in pain and disability.1 Pain-related TMD can impact the individual's daily activities, psychosocial functioning, and quality of life. Overall, the annual TMD management cost in the USA, not including imaging, has doubled in the last decade to $4 billion.1
Patients often seek consultation with dentists for their TMD, especially for pain-related TMD. Diagnostic criteria for TMD with simple, clear, reliable, and valid operational definitions for the history, examination, and imaging procedures are needed to render physical diagnoses in both clinical and research settings. In addition, biobehavioral assessment of pain-related behavior and psychosocial functioning—an essential part of the diagnostic process—is required and provides the minimal information whereby one can determine whether the patient's pain disorder, especially when chronic, warrants further multidisciplinary assessment. Taken together, a new dual-axis Diagnostic Criteria for TMD (DC/TMD) will provide evidence-based criteria for the clinician to use when assessing patients, and will facilitate communication regarding consultations, referrals, and prognosis.2
The research community benefits from the ability to use well-defined and clinically relevant characteristics associated with the phenotype in order to facilitate more generalizable research. When clinicians and researchers use the same criteria, taxonomy, and nomenclature, then clinical questions and experience can be more easily transferred into relevant research questions, and research findings are more accessible to clinicians to better diagnose and manage their patients. The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) have been the most widely employed diagnostic protocol for TMD research since its publication in 1992.3 This classification system was based on the biopsychosocial model of pain4 that included an Axis I physical assessment, using reliable and well-operationalized diagnostic criteria, and an Axis II assessment of psychosocial status and pain-related disability. The intent was to simultaneously provide a physical diagnosis and identify other relevant characteristics of the patient that could influence the expression and thus management of their TMD. Indeed, the longer the pain persists, the greater the potential for emergence and amplification of cognitive, psychosocial, and behavioral risk factors, with resultant enhanced pain sensitivity, greater likelihood of additional pain persistence, and reduced probability of success from standard treatments.5
The RDC/TMD (1992) was intended to be only a first step toward improved TMD classification, and the authors stated the need for future investigation of the accuracy of the Axis I diagnostic algorithms in terms of reliability and criterion validity—the latter involving the use of credible reference standard diagnoses. Also recommended was further assessment of the clinical utility of the Axis II instruments. The original RDC/TMD Axis I physical diagnoses have content validity based on the critical review by experts of the published diagnostic approach in use at that time and were tested using population-based epidemiologic data.6 Subsequently, a multicenter study showed that, for the most common TMD, the original RDC/TMD diagnoses exhibited sufficient reliability for clinical use.7 While the validity of the individual RDC/TMD diagnoses has been extensively investigated, assessment of the criterion validity for the complete spectrum of RDC/TMD diagnoses had been absent until recently.8
For the original RDC/TMD Axis II instruments, good evidence for their reliability and validity for measuring psychosocial status and pain-related disability already existed when the classification system was published.9–13 Subsequently, a variety of studies have demonstrated the significance and utility of the original RDC/TMD biobehavioral measures in such areas as predicting outcomes of clinical trials, escalation from acute to chronic pain, and experimental laboratory settings.14–20
Other studies have shown that the original RDC/TMD biobehavioral measures are incomplete in terms of prediction of disease course.21–23 The overall utility of the biobehavioral measures in routine clinical settings has, however, yet to be demonstrated, in part because most studies have to date focused on Axis I diagnoses rather than Axis II biobehavioral factors.24
The aims of this article are to present the evidence-based new Axis I and Axis II DC/TMD to be used in both clinical and research settings, as well as present the processes related to their development.
2,283 citations
TL;DR: Applications in Theranostics Guanying Chen,*,†,‡ Hailong Qiu,*,‡ and Xiaoyuan Chen.
Abstract: Applications in Theranostics Guanying Chen,*,†,‡ Hailong Qiu,†,‡ Paras N. Prasad,*,‡,§ and Xiaoyuan Chen* †School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China ‡Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, State University of New York, Buffalo, New York 14260, United States Department of Chemistry, Korea University, Seoul 136-701, Korea Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892-2281, United States
1,994 citations
TL;DR: This work provides practitioners with a set of “good practice” recommendations for designing and implementing an accuracy assessment of a change map and estimating area based on the reference sample data.
1,708 citations
TL;DR: Findings from school, work, and physical domains and meta-analysis indicate that intrinsic motivation is a medium to strong predictor of performance, and incentive salience influenced the predictive validity of intrinsic motivation for performance.
Abstract: More than 4 decades of research and 9 meta-analyses have focused on the undermining effect: namely, the debate over whether the provision of extrinsic incentives erodes intrinsic motivation. This review and meta-analysis builds on such previous reviews by focusing on the interrelationship among intrinsic motivation, extrinsic incentives, and performance, with reference to 2 moderators: performance type (quality vs. quantity) and incentive contingency (directly performance-salient vs. indirectly performance-salient), which have not been systematically reviewed to date. Based on random-effects meta-analytic methods, findings from school, work, and physical domains (k = 183, N = 212,468) indicate that intrinsic motivation is a medium to strong predictor of performance (ρ = .21-45). The importance of intrinsic motivation to performance remained in place whether incentives were presented. In addition, incentive salience influenced the predictive validity of intrinsic motivation for performance: In a "crowding out" fashion, intrinsic motivation was less important to performance when incentives were directly tied to performance and was more important when incentives were indirectly tied to performance. Considered simultaneously through meta-analytic regression, intrinsic motivation predicted more unique variance in quality of performance, whereas incentives were a better predictor of quantity of performance. With respect to performance, incentives and intrinsic motivation are not necessarily antagonistic and are best considered simultaneously. Future research should consider using nonperformance criteria (e.g., well-being, job satisfaction) as well as applying the percent-of-maximum-possible (POMP) method in meta-analyses.
1,231 citations
TL;DR: An in-depth view of Terahertz Band (0.1-10 THz) communication, which is envisioned as a key technology to satisfy the increasing demand for higher speed wireless communication, is provided.
1,206 citations
TL;DR: The results demonstrate that without proper waste management, low-density populations can heavily pollute freshwater systems with consumer plastics.
977 citations
TL;DR: A comprehensive and structured overview of a large set of interesting outlier definitions for various forms of temporal data, novel techniques, and application scenarios in which specific definitions and techniques have been widely used is provided.
Abstract: In the statistics community, outlier detection for time series data has been studied for decades. Recently, with advances in hardware and software technology, there has been a large body of work on temporal outlier detection from a computational perspective within the computer science community. In particular, advances in hardware technology have enabled the availability of various forms of temporal data collection mechanisms, and advances in software technology have enabled a variety of data management mechanisms. This has fueled the growth of different kinds of data sets such as data streams, spatio-temporal data, distributed streams, temporal networks, and time series data, generated by a multitude of applications. There arises a need for an organized and detailed study of the work done in the area of outlier detection with respect to such temporal datasets. In this survey, we provide a comprehensive and structured overview of a large set of interesting outlier definitions for various forms of temporal data, novel techniques, and application scenarios in which specific definitions and techniques have been widely used.
851 citations
California Institute of Technology1, University of California, Davis2, University of Tennessee3, Imperial College London4, Arizona State University5, United States Geological Survey6, Princeton University7, Indiana University8, University of Nantes9, Brown University10, Goddard Space Flight Center11, Ames Research Center12, State University of New York System13, Jacobs Engineering Group14, Planetary Science Institute15, University of Guelph16, Los Alamos National Laboratory17, University of Toulouse18, Smithsonian Institution19, Washington University in St. Louis20, University of Washington21, University of California, Berkeley22, University of Lyon23, University of Texas at Austin24, Rensselaer Polytechnic Institute25, Canadian Space Agency26, NASA Headquarters27, University of New Mexico28, University of Hawaii at Manoa29, Brock University30, Cornell University31, Carnegie Institution for Science32, Massachusetts Institute of Technology33, Lunar and Planetary Institute34
TL;DR: The Curiosity rover discovered fine-grained sedimentary rocks, which are inferred to represent an ancient lake and preserve evidence of an environment that would have been suited to support a martian biosphere founded on chemolithoautotrophy.
Abstract: The Curiosity rover discovered fine-grained sedimentary rocks, which are inferred to represent an ancient lake and preserve evidence of an environment that would have been suited to support a martian biosphere founded on chemolithoautotrophy. This aqueous environment was characterized by neutral pH, low salinity, and variable redox states of both iron and sulfur species. Carbon, hydrogen, oxygen, sulfur, nitrogen, and phosphorus were measured directly as key biogenic elements; by inference, phosphorus is assumed to have been available. The environment probably had a minimum duration of hundreds to tens of thousands of years. These results highlight the biological viability of fluvial-lacustrine environments in the post-Noachian history of Mars.
770 citations
01 Jan 2014
TL;DR: The history of attitude sensor development has emphasized increased resolution and accuracy as well as decreased size, weight, and power (often abbreviated as SWaP).
Abstract: This chapter will discuss several kinds of sensors and actuators used to determine and control spacecraft attitude [26, 44, 54, 66]. The history of attitude sensor development has emphasized increased resolution and accuracy as well as decreased size, weight, and power (often abbreviated as SWaP). Actuator technologies have also been scaled down to be appropriate for microsatellites and cubesats. We begin with a brief introduction to redundancy considerations, and then consider some specific sensors and actuators.
740 citations
TL;DR: It is proposed that the “high-versus-low wall shear stress” controversy is a manifestation of the complexity of aneurysm pathophysiology, and both high and low wallShear stress can drive intracranial aneurYSm growth and rupture.
Abstract: Summary: Increasing detection of unruptured intracranial aneurysms, catastrophic outcomes from subarachnoid hemorrhage, and risks and cost of treatment necessitate defining objective predictive parameters of aneurysm rupture risk. Image-based computational fluid dynamics models have suggested associations between hemodynamics and intracranial aneurysm rupture, albeit with conflicting findings regarding wall shear stress. We propose that the “high-versus-low wall shear stress” controversy is a manifestation of the complexity of aneurysm pathophysiology, and both high and low wall shear stress can drive intracranial aneurysm growth and rupture. Low wall shear stress and high oscillatory shear index trigger an inflammatory-cell-mediated pathway, which could be associated with the growth and rupture of large, atherosclerotic aneurysm phenotypes, while high wall shear stress combined with a positive wall shear stress gradient trigger a mural-cell-mediated pathway, which could be associated with the growth and rupture of small or secondary bleb aneurysm phenotypes. This hypothesis correlates disparate intracranial aneurysm pathophysiology with the results of computational fluid dynamics in search of more reliable risk predictors.
670 citations
State University of New York System1, McGill University2, University of Connecticut3, Cornell University4, Umeå University5, Wayne State University6, University of Iowa7, University of Miami8, University of Pennsylvania9, Mayo Clinic10, University of Sydney11, University of Buenos Aires12, University of Chicago13, Shanghai Jiao Tong University14, North-West University15, University of Rochester16, University of Glasgow17, Virginia Commonwealth University18, University of Melbourne19
TL;DR: Clinical practice guidelines for the management of hypertension in the community a statement by the American Society of Hypertension and the International Society of hypertension as mentioned in this paper, which is based on guidelines from the National Institute of Neurological Disorders and Strochastic Hemorrhage.
Abstract: Clinical practice guidelines for the management of hypertension in the community a statement by the American society of hypertension and the International society of hypertension
TL;DR: A global symmetry is a symmetry for which the charged operators are of space-time dimension $q$; e.g., strings, membranes, etc. as mentioned in this paper Theorem 1.
Abstract: A $q$-form global symmetry is a global symmetry for which the charged operators are of space-time dimension $q$; e.g. Wilson lines, surface defects, etc., and the charged excitations have $q$ spatial dimensions; e.g. strings, membranes, etc. Many of the properties of ordinary global symmetries ($q$=0) apply here. They lead to Ward identities and hence to selection rules on amplitudes. Such global symmetries can be coupled to classical background fields and they can be gauged by summing over these classical fields. These generalized global symmetries can be spontaneously broken (either completely or to a subgroup). They can also have 't Hooft anomalies, which prevent us from gauging them, but lead to 't Hooft anomaly matching conditions. Such anomalies can also lead to anomaly inflow on various defects and exotic Symmetry Protected Topological phases. Our analysis of these symmetries gives a new unified perspective of many known phenomena and uncovers new results.
Washington University in St. Louis1, Medical University of South Carolina2, Emory University3, State University of New York System4, Oregon Health & Science University5, University of Florida6, University at Buffalo7, University of Alabama at Birmingham8, Houston Methodist Hospital9, Barrow Neurological Institute10, University of Texas Southwestern Medical Center11, Medical College of Wisconsin12, Mayo Clinic13
TL;DR: The findings lend support to the use of aggressive medical management rather than PTAS with the Wingspan system in high-risk patients with atherosclerotic intracranial arterial stenosis.
Planetary Science Institute1, Indiana University2, Ames Research Center3, Chesapeake Energy4, University of Arizona5, Lunar and Planetary Institute6, California Institute of Technology7, UTC Aerospace Systems8, State University of New York System9, University of New Mexico10, Arizona State University11, University of Toulouse12, Search for extraterrestrial intelligence13, Brown University14, University of California, Davis15, Imperial College London16
TL;DR: Sedimentary rocks at Yellowknife Bay (Gale crater) on Mars include mudstone sampled by the Curiosity rover, indicating that clay mineral formation on Mars extended beyond Noachian time.
Abstract: Sedimentary rocks at Yellowknife Bay (Gale crater) on Mars include mudstone sampled by the Curiosity rover. The samples, John Klein and Cumberland, contain detrital basaltic minerals, calcium sulfates, iron oxide or hydroxides, iron sulfides, amorphous material, and trioctahedral smectites. The John Klein smectite has basal spacing of similar to 10 angstroms, indicating little interlayer hydration. The Cumberland smectite has basal spacing at both similar to 13.2 and similar to 10 angstroms. The larger spacing suggests a partially chloritized interlayer or interlayer magnesium or calcium facilitating H2O retention. Basaltic minerals in the mudstone are similar to those in nearby eolian deposits. However, the mudstone has far less Fe-forsterite, possibly lost with formation of smectite plus magnetite. Late Noachian/Early Hesperian or younger age indicates that clay mineral formation on Mars extended beyond Noachian time.
TL;DR: Higher Hcy levels, lower educational attainment, and decreased physical activity were particularly strong predictors of incident AD, and further studies are needed to support other potential modifiable protective factors, such as caffeine.
Abstract: Cognitive impairment, including dementia, is a major health concern with the increasing aging population. Preventive measures to delay cognitive decline are of utmost importance. Alzheimer’s disease (AD) is the most frequent cause of dementia, increasing in prevalence from 40% above 85 years of age. We systematically reviewed selected modifiable factors such as education, smoking, alcohol, physical activity, caffeine, antioxidants, homocysteine (Hcy), n-3 fatty acids that were studied in relation to various cognitive health outcomes, including incident AD. We searched MEDLINE for published literature (January 1990 through October 2012), including cross-sectional and cohort studies (sample sizes > 300). Analyses compared study finding consistency across factors, study designs and study-level characteristics. Selecting studies of incident AD, our meta-analysis estimated pooled risk ratios (RR), population attributable risk percent (PAR%) and assessed publication bias. In total, 247 studies were retrieved for systematic review. Consistency analysis for each risk factor suggested positive findings ranging from ~38.9% for caffeine to ~89% for physical activity. Education also had a significantly higher propensity for “a positive finding” compared to caffeine, smoking and antioxidant-related studies. Meta-analysis of 31 studies with incident AD yielded pooled RR for low education (RR = 1.99; 95% CI: 1.30-3.04), high Hcy (RR = 1.93; 95% CI: 1.50-2.49), and current/ever smoking status (RR = 1.37; 95% CI: 1.23-1.52) while indicating protective effects of higher physical activity and n-3 fatty acids. Estimated PAR% were particularly high for physical activity (PAR% = 31.9; 95% CI: 22.7-41.2) and smoking (PAR%=31.09%; 95% CI: 17.9-44.3). Overall, no significant publication bias was found. Higher Hcy levels, lower educational attainment, and decreased physical activity were particularly strong predictors of incident AD. Further studies are needed to support other potential modifiable protective factors, such as caffeine.
University of Amsterdam1, Harvard University2, Oslo University Hospital3, State University of New York System4, University of California, San Francisco5, Pfizer6, University of Sydney7, Wesley Hospital8, Queen Mary University of London9, University College London10, Touro University California11, University of Texas Health Science Center at San Antonio12, University of Dundee13, Cornell University14, University of Texas at Dallas15
TL;DR: Patients who achieve very low LDL-C levels have a lower risk for major cardiovascular events than do those achieving moderately low levels and the association between very low levels of atherogenic lipoproteins achieved with statin therapy and cardiovascular disease risk is well-documented.
State University of New York System1, Centre de coopération internationale en recherche agronomique pour le développement2, ENEA3, University of Ottawa4, French Alternative Energies and Atomic Energy Commission5, Bioversity International6, Nestlé7, Bielefeld University8, Institut national de la recherche agronomique9, Chongqing University of Science and Technology10, University of Illinois at Urbana–Champaign11, University of Barcelona12, University of Maryland, College Park13, University of Trieste14, Empresa Brasileira de Pesquisa Agropecuária15, Analytica16, University of Queensland17, Coffee production in India18, University of Arizona19, Centre national de la recherche scientifique20, University of Évry Val d'Essonne21
TL;DR: The Coffea canephora (coffee) genome was sequenced and identified a conserved gene order, and comparative analyses of caffeine NMTs demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.
Abstract: Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although it shows no sign of the whole-genome triplication identified in Solanaceae species such as tomato, the genome includes several species-specific gene family expansions, among them N-methyltransferases (NMTs) involved in caffeine production, defense-related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis. Comparative analyses of caffeine NMTs demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.
University of Colorado Boulder1, National Oceanic and Atmospheric Administration2, Morgan State University3, National Center for Atmospheric Research4, Cooperative Institute for Research in Environmental Sciences5, State University of New York System6, Goddard Space Flight Center7, University of Toulouse8, Tsinghua University9
TL;DR: In this paper, an up-to-date overview of tropospheric ozone distribution and trends is presented, along with some new and extended analyses using well-known and referenced datasets to draw connections between ozone trends and distributions in different regions of the world.
Abstract: Tropospheric ozone plays a major role in Earth’s atmospheric chemistry processes and also acts as an air pollutant and greenhouse gas. Due to its short lifetime, and dependence on sunlight and precursor emissions from natural and anthropogenic sources, tropospheric ozone’s abundance is highly variable in space and time on seasonal, interannual and decadal time-scales. Recent, and sometimes rapid, changes in observed ozone mixing ratios and ozone precursor emissions inspired us to produce this up-to-date overview of tropospheric ozone’s global distribution and trends. Much of the text is a synthesis of in situ and remotely sensed ozone observations reported in the peer-reviewed literature, but we also include some new and extended analyses using well-known and referenced datasets to draw connections between ozone trends and distributions in different regions of the world. In addition, we provide a brief evaluation of the accuracy of rural or remote surface ozone trends calculated by three state-of-the-science chemistry-climate models, the tools used by scientists to fill the gaps in our knowledge of global tropospheric ozone distribution and trends.
TL;DR: Satellite measurements of land surface temperature (LST) from planted forests and adjacent grasslands or croplands in China are used to understand how afforestation affects LST and suggest it is necessary to carefully consider where to plant trees to achieve potential climatic benefits in future Afforestation projects.
Abstract: China has the largest afforested area in the world (∼62 million hectares in 2008), and these forests are carbon sinks. The climatic effect of these new forests depends on how radiant and turbulent energy fluxes over these plantations modify surface temperature. For instance, a lower albedo may cause warming, which negates the climatic benefits of carbon sequestration. Here, we used satellite measurements of land surface temperature (LST) from planted forests and adjacent grasslands or croplands in China to understand how afforestation affects LST. Afforestation is found to decrease daytime LST by about 1.1 ± 0.5 °C (mean ± 1 SD) and to increase nighttime LST by about 0.2 ± 0.5 °C, on average. The observed daytime cooling is a result of increased evapotranspiration. The nighttime warming is found to increase with latitude and decrease with average rainfall. Afforestation in dry regions therefore leads to net warming, as daytime cooling is offset by nighttime warming. Thus, it is necessary to carefully consider where to plant trees to realize potential climatic benefits in future afforestation projects.
Johns Hopkins University1, Southern Illinois University School of Medicine2, State University of New York System3, University of Kentucky4, University of Manitoba5, Tulane University6, Columbia University7, Portland VA Medical Center8, Ochsner Health System9, George Washington University10, Cleveland Clinic Lerner College of Medicine11, Morehouse School of Medicine12, NewYork–Presbyterian Hospital13, University of California, San Diego14, University of California, Los Angeles15, University of Iowa16, University of Alabama17
TL;DR: This guideline provides clinicians with a logical framework to improve patient care and mitigate the personal and social effects of persistent, bothersome tinnitus.
Abstract: Objective. Tinnitus is the perception of sound without an external source. More than 50 million people in the United States have reported experiencing tinnitus, resulting in an estimated prevalence of 10% to 15% in adults. Despite the high prevalence of tinnitus and its potential significant effect on quality of life, there are no evidence-based, multidisciplinary clinical practice guidelines to assist clinicians with management. The focus of this guideline is on tinnitus that is both bothersome and persistent (lasting 6 months or longer), which often negatively affects the patient’s quality of life. The target audience for the guideline is any clinician, including nonphysicians, involved in managing patients with tinnitus. The target patient population is limited to adults (18 years and older) with primary tinnitus that is persistent and bothersome. Purpose. The purpose of this guideline is to provide evidence-based recommendations for clinicians managing patients with tinnitus. This guideline provides clinicians with a logical framework to improve patient care and mitigate the personal and social effects of persistent, bothersome tinnitus. It will discuss the evaluation of patients with tinnitus, including selection and timing of diagnostic testing and specialty referral to identify potential underlying treatable pathology. It will then focus on the evaluation and treatment of patients with persistent primary tinnitus, with recommendations to guide the evaluation and measurement of the effect of tinnitus and to determine the most appropriate interventions to improve symptoms and quality of life for tinnitus sufferers. Action Statements. The development group made a strong recommendation that clinicians distinguish patients with bothersome tinnitus from patients with nonbothersome tinnitus. The development group made a strong recommendation against obtaining imaging studies of the head and neck in patients with tinnitus, specifically to evaluate tinnitus that does not localize to 1 ear, is nonpulsatile, and is not associated with focal neurologic abnormalities or an asymmetric hearing loss. The panel made the following recommendations: Clinicians should (a) perform a targeted history and physical examination at the initial evaluation of a patient with presumed primary tinnitus to identify conditions that if promptly identified and managed may relieve tinnitus; (b) obtain a prompt, comprehensive audiologic examination in patients with tinnitus that is unilateral, persistent (≥ 6 months), or associated with hearing difficulties; (c) distinguish patients with bothersome tinnitus of recent onset from those with persistent symptoms (≥ 6 months) to prioritize intervention and facilitate discussions about natural history and follow-up care; (d) educate patients with persistent, bothersome tinnitus about management strategies; (e) recommend a hearing aid evaluation for patients who have persistent, bothersome tinnitus associated with documented hearing loss; and (f) recommend cognitive behavioral therapy to patients with persistent, bothersome tinnitus. The panel recommended against (a) antidepressants, anticonvulsants, anxiolytics, or intratympanic medications for the routine treatment of patients with persistent, bothersome tinnitus; (b) Ginkgo biloba, melatonin, zinc, or other dietary supplements for treating patients with persistent, bothersome tinnitus; and (c) transcranial magnetic stimulation for the routine treatment of patients with persistent, bothersome tinnitus. The development group provided the following options: Clinicians may (a) obtain an initial comprehensive audiologic examination in patients who present with tinnitus (regardless of laterality, duration, or perceived hearing status); 545325
QIMR Berghofer Medical Research Institute1, University of Queensland2, Royal Melbourne Hospital3, University of Vermont4, Kuwait University5, University of Toronto6, Aalborg University7, Leiden University8, French Institute of Health and Medical Research9, University of Edinburgh10, University Hospital of Wales11, University of Rouen12, Huntsman Cancer Institute13, University of Utah14, University of Connecticut Health Center15, Ludwig Maximilian University of Munich16, University of Western Sydney17, Garvan Institute of Medical Research18, University of New South Wales19, Karolinska University Hospital20, University of Hong Kong21, Oslo University Hospital22, University of Helsinki23, Zhejiang University24, University of Rochester Medical Center25, University of Cape Town26, University of Copenhagen27, University of Düsseldorf28, University of Newcastle29, John Hunter Hospital30, University Medical Center Groningen31, State University of New York System32, Memorial University of Newfoundland33, University of Florence34
TL;DR: This large-scale endeavor will facilitate the consistent management of families suspected to have Lynch syndrome and demonstrates the value of multidisciplinary collaboration in the curation and classification of variants in public locus-specific databases.
Abstract: The clinical classification of hereditary sequence variants identified in disease-related genes directly affects clinical management of patients and their relatives. The International Society for Gastrointestinal Hereditary Tumours (InSiGHT) undertook a collaborative effort to develop, test and apply a standardized classification scheme to constitutional variants in the Lynch syndrome-associated genes MLH1, MSH2, MSH6 and PMS2. Unpublished data submission was encouraged to assist in variant classification and was recognized through microattribution. The scheme was refined by multidisciplinary expert committee review of the clinical and functional data available for variants, applied to 2,360 sequence alterations, and disseminated online. Assessment using validated criteria altered classifications for 66% of 12,006 database entries. Clinical recommendations based on transparent evaluation are now possible for 1,370 variants that were not obviously protein truncating from nomenclature. This large-scale endeavor will facilitate the consistent management of families suspected to have Lynch syndrome and demonstrates the value of multidisciplinary collaboration in the curation and classification of variants in public locus-specific databases.
TL;DR: Choukroun's platelet-rich fibrin (PRF) is obtained from blood without adding anticoagulants and might influence bone and soft tissue regeneration, especially through the presence of monocytes/macrophages and their growth factors.
Abstract: Choukroun's platelet-rich fibrin (PRF) is obtained from blood without adding anticoagulants. In this study, protocols for standard platelet-rich fibrin (S-PRF) (2700 rpm, 12 minutes) and advanced p...
TL;DR: Bacterial and human PDCs are compared, as they represent the two major classes of the superfamily of 2-oxo acid dehydrogenase complexes with different assembly of, and interactions among components.
TL;DR: This work proposes and realizes an electronic MD based on a single-electron box operated as a Szilard engine, where kBT ln 2 of heat is extracted from the reservoir at temperature T per one bit of created information.
Abstract: The most succinct manifestation of the second law of thermodynamics is the limitation imposed by the Landauer principle on the amount of heat a Maxwell demon (MD) can convert into free energy per single bit of information obtained in a measurement We propose and realize an electronic MD based on a single-electron box operated as a Szilard engine, where kBT ln 2 of heat is extracted from the reservoir at temperature T per one bit of created information The information is encoded in the position of an extra electron in the box
TL;DR: In this article, a broad selection of stochastic frontier models based on different assumptions and specifications of heterogeneity, heteroskedasticity and technical inefficiency were used to estimate technical efficiency of Norwegian grain farmers.
Abstract: Estimation of technical efficiency is widely used in empirical research using both cross-sectional and panel data. Although several stochastic frontier models for panel data are available, only a few of them are normally applied in empirical research. In this article we chose a broad selection of such models based on different assumptions and specifications of heterogeneity, heteroskedasticity and technical inefficiency. We applied these models to a single dataset from Norwegian grain farmers for the period 2004–2008. We also introduced a new model that disentangles firm effects from persistent (time-invariant) and residual (time-varying) technical inefficiency. We found that efficiency results are quite sensitive to how inefficiency is modeled and interpreted. Consequently, we recommend that future empirical research should pay more attention to modeling and interpreting inefficiency as well as to the assumptions underlying each model when using panel data.
Columbia University1, Goddard Institute for Space Studies2, University of Crete3, Foundation for Research & Technology – Hellas4, Carnegie Mellon University5, University of São Paulo6, University of California, San Diego7, University of Reading8, Met Office9, European Centre for Medium-Range Weather Forecasts10, Finnish Meteorological Institute11, University of Oslo12, North-West University13, University of Maryland, College Park14, University of Leeds15, Goddard Space Flight Center16, University of L'Aquila17, Universities Space Research Association18, Pacific Northwest National Laboratory19, Meteorological Service of Canada20, National Center for Atmospheric Research21, Swiss Federal Institute for Forest, Snow and Landscape Research22, Paul Scherrer Institute23, Norwegian Meteorological Institute24, University of Colorado Boulder25, Max Planck Society26, University of Michigan27, University of Wyoming28, State University of New York System29, Environment Canada30, Belgian Institute for Space Aeronomy31, Georgia Institute of Technology32, Istanbul Technical University33, Duke University34, Kyushu University35, University of Eastern Finland36, University of Mainz37, Royal Netherlands Meteorological Institute38, China Meteorological Administration39, University of California, Davis40
TL;DR: In this article, the current status of global modeling of the organic aerosol (OA) in the troposphere and analyzes the differences between models as well as between models and observations.
Abstract: . This paper evaluates the current status of global modeling of the organic aerosol (OA) in the troposphere and analyzes the differences between models as well as between models and observations. Thirty-one global chemistry transport models (CTMs) and general circulation models (GCMs) have participated in this intercomparison, in the framework of AeroCom phase II. The simulation of OA varies greatly between models in terms of the magnitude of primary emissions, secondary OA (SOA) formation, the number of OA species used (2 to 62), the complexity of OA parameterizations (gas-particle partitioning, chemical aging, multiphase chemistry, aerosol microphysics), and the OA physical, chemical and optical properties. The diversity of the global OA simulation results has increased since earlier AeroCom experiments, mainly due to the increasing complexity of the SOA parameterization in models, and the implementation of new, highly uncertain, OA sources. Diversity of over one order of magnitude exists in the modeled vertical distribution of OA concentrations that deserves a dedicated future study. Furthermore, although the OA / OC ratio depends on OA sources and atmospheric processing, and is important for model evaluation against OA and OC observations, it is resolved only by a few global models. The median global primary OA (POA) source strength is 56 Tg a−1 (range 34–144 Tg a−1) and the median SOA source strength (natural and anthropogenic) is 19 Tg a−1 (range 13–121 Tg a−1). Among the models that take into account the semi-volatile SOA nature, the median source is calculated to be 51 Tg a−1 (range 16–121 Tg a−1), much larger than the median value of the models that calculate SOA in a more simplistic way (19 Tg a−1; range 13–20 Tg a−1, with one model at 37 Tg a−1). The median atmospheric burden of OA is 1.4 Tg (24 models in the range of 0.6–2.0 Tg and 4 between 2.0 and 3.8 Tg), with a median OA lifetime of 5.4 days (range 3.8–9.6 days). In models that reported both OA and sulfate burdens, the median value of the OA/sulfate burden ratio is calculated to be 0.77; 13 models calculate a ratio lower than 1, and 9 models higher than 1. For 26 models that reported OA deposition fluxes, the median wet removal is 70 Tg a−1 (range 28–209 Tg a−1), which is on average 85% of the total OA deposition. Fine aerosol organic carbon (OC) and OA observations from continuous monitoring networks and individual field campaigns have been used for model evaluation. At urban locations, the model–observation comparison indicates missing knowledge on anthropogenic OA sources, both strength and seasonality. The combined model–measurements analysis suggests the existence of increased OA levels during summer due to biogenic SOA formation over large areas of the USA that can be of the same order of magnitude as the POA, even at urban locations, and contribute to the measured urban seasonal pattern. Global models are able to simulate the high secondary character of OA observed in the atmosphere as a result of SOA formation and POA aging, although the amount of OA present in the atmosphere remains largely underestimated, with a mean normalized bias (MNB) equal to −0.62 (−0.51) based on the comparison against OC (OA) urban data of all models at the surface, −0.15 (+0.51) when compared with remote measurements, and −0.30 for marine locations with OC data. The mean temporal correlations across all stations are low when compared with OC (OA) measurements: 0.47 (0.52) for urban stations, 0.39 (0.37) for remote stations, and 0.25 for marine stations with OC data. The combination of high (negative) MNB and higher correlation at urban stations when compared with the low MNB and lower correlation at remote sites suggests that knowledge about the processes that govern aerosol processing, transport and removal, on top of their sources, is important at the remote stations. There is no clear change in model skill with increasing model complexity with regard to OC or OA mass concentration. However, the complexity is needed in models in order to distinguish between anthropogenic and natural OA as needed for climate mitigation, and to calculate the impact of OA on climate accurately.
TL;DR: The development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and give rise to good optical contrast for photoacoustic imaging is reported.
Abstract: There is a need for safer and improved methods for non-invasive imaging of the gastrointestinal tract. Modalities based on X-ray radiation, magnetic resonance and ultrasound suffer from limitations with respect to safety, accessibility or lack of adequate contrast. Functional intestinal imaging of dynamic gut processes has not been practical using existing approaches. Here, we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and provide good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate purified ∼ 20 nm frozen micelles, which we call nanonaps, with tunable and large near-infrared absorption values (>1,000). Unlike conventional chromophores, nanonaps exhibit non-shifting spectra at ultrahigh optical densities and, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution, and enabled real-time intestinal functional imaging with ultrasound co-registration. Positron emission tomography following seamless nanonap radiolabelling allowed complementary whole-body imaging.
State University of New York System1, National Oceanic and Atmospheric Administration2, Boston University3, Centre national de la recherche scientifique4, Jet Propulsion Laboratory5, University of New South Wales6, Peking University7, Nanjing University of Information Science and Technology8, Goddard Space Flight Center9, University of North Carolina at Chapel Hill10
TL;DR: Observational evidence for a widespread decline in forest greenness over the past decade is presented based on analyses of satellite data from several independent sensors over the Congo basin, suggesting a continued gradual decline of photosynthetic capacity and moisture content driven by the persistent drying trend could alter the composition and structure of the Congolese forest to favour the spread of drought-tolerant species.
Abstract: Tropical forests are global epicentres of biodiversity and important modulators of climate change, and are mainly constrained by rainfall patterns. The severe short-term droughts that occurred recently in Amazonia have drawn attention to the vulnerability of tropical forests to climatic disturbances. The central African rainforests, the second-largest on Earth, have experienced a long-term drying trend whose impacts on vegetation dynamics remain mostly unknown because in situ observations are very limited. The Congolese forest, with its drier conditions and higher percentage of semi-evergreen trees, may be more tolerant to short-term rainfall reduction than are wetter tropical forests, but for a long-term drought there may be critical thresholds of water availability below which higher-biomass, closed-canopy forests transition to more open, lower-biomass forests. Here we present observational evidence for a widespread decline in forest greenness over the past decade based on analyses of satellite data (optical, thermal, microwave and gravity) from several independent sensors over the Congo basin. This decline in vegetation greenness, particularly in the northern Congolese forest, is generally consistent with decreases in rainfall, terrestrial water storage, water content in aboveground woody and leaf biomass, and the canopy backscatter anomaly caused by changes in structure and moisture in upper forest layers. It is also consistent with increases in photosynthetically active radiation and land surface temperature. These multiple lines of evidence indicate that this large-scale vegetation browning, or loss of photosynthetic capacity, may be partially attributable to the long-term drying trend. Our results suggest that a continued gradual decline of photosynthetic capacity and moisture content driven by the persistent drying trend could alter the composition and structure of the Congolese forest to favour the spread of drought-tolerant species.
TL;DR: The high photocurrent response is attributed to the direct band gap of In2Se3 combined with a large surface-area-to-volume ratio and a self-terminated/native-oxide-free surface, which help to reduce carrier recombination while keeping fast response, allowing for real-time detection under very low-light conditions.
Abstract: We demonstrate extraordinary photoconductive behavior in two-dimensional (2D) crystalline indium selenide (In2Se3) nanosheets. Photocurrent measurements reveal that semiconducting In2Se3 nanosheets have an extremely high response to visible light, exhibiting a photoresponsivity of 3.95 × 102 A·W–1 at 300 nm with an external quantum efficiency greater than 1.63 × 105 % at 5 V bias. The key figures-of-merit exceed that of graphene and other 2D material-based photodetectors reported to date. In addition, the photodetector has a fast response time of 1.8 × 10–2 s and a specific detectivity of 2.26 × 1012 Jones. The photoconductive response of α-In2Se3 nanosheets extends into ultraviolet, visible, and near-infrared spectral regions. The high photocurrent response is attributed to the direct band gap (EG = 1.3 eV) of In2Se3 combined with a large surface-area-to-volume ratio and a self-terminated/native-oxide-free surface, which help to reduce carrier recombination while keeping fast response, allowing for real-...
TL;DR: In this article, the authors found that higher support and lower strain received from each of the four relational sources (spouse/partner, children, family, and friends) were associated with reduced loneliness and improved well-being.
Abstract: This study proposed that, among older adults, higher support and lower strain received from each of the four relational sources (spouse/partner, children, family, and friends) were associated with reduced loneliness and improved well-being and that loneliness might mediate the relationship between support/strain and well-being. Structural equation modeling was conducted using a national sample of adults aged 50 years and older (N = 7,367) from the Health and Retirement Study. Findings indicated that support from spouse/partner and friends alleviated loneliness, while strain from all the four sources intensified loneliness; higher support and lower strain from various sources directly and indirectly improved well-being, with indirect effects mediated through reduced loneliness. It was concluded that, in later life, various sources of support/strain engender distinct effects on loneliness and well-being, and loneliness serves as one of the psychological pathways linking support/strain to well-being.