Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Systemic inflammation and intelligence in early adulthood and subsequent risk of schizophrenia and other non-affective psychoses: a longitudinal cohort and co-relative study.
Nils Kappelmann,Gulam Khandaker,Henrik Dal,Jan Stochl,Kyriaki Kosidou,Peter B. Jones,Christina Dalman,Håkan Karlsson +7 more
TL;DR: Lower IQ is associated with low-grade systemic inflammation and with an increased risk of schizophrenia and ONAP in adulthood andLow-grade inflammation may influence schizophrenia risk by affecting neurodevelopment.
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The schizophrenia prodrome: a developmentally informed review and update for psychopharmacologic treatment.
Lynelle E. Thomas,Scott W. Woods +1 more
TL;DR: Preliminary data suggest that atypical antipsychotic medications may improve symptoms and delay or prevent progression to schizophrenia, but substantial additional research is needed before the balance of long-term risks and benefits can be confidently assessed.
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Prevalence of nonaffective psychosis in intellectually disabled clients: systematic review and meta-analysis.
TL;DR: The prevalence of psychosis in a population with ID is at least three times higher than that in the general population and there was a wide variation in the methodology, setting and sample size of the studies.
Journal ArticleDOI
Differences in subcortical structures in young adolescents at familial risk for schizophrenia: A preliminary study
Michael K. Dougherty,Hongbin Gu,Joshua Bizzell,Joshua Bizzell,Stacy Ramsey,Guido Gerig,Diana O. Perkins,Aysenil Belger,Aysenil Belger +8 more
TL;DR: The results suggest that relatives of individuals with schizophrenia exhibit structural abnormalities in the subcortex as early as pre-adolescence, which may reflect altered neurodevelopment of these regions.
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Self‐awareness of functional impairment in individuals at clinical high‐risk for psychosis
Doreen M. Olvet,Ricardo E. Carrión,Andrea M. Auther,Andrea M. Auther,Barbara A. Cornblatt,Barbara A. Cornblatt +5 more
TL;DR: This study aims to examine the relationship between clinician‐based and self‐report assessments of functioning, as well as the contribution of clinical symptoms to this relationship in individuals at clinical high‐risk for psychosis.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.