Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Journal ArticleDOI
The Maudsley Family Study: Premorbid and Current General Intellectual Function Levels in Familial Bipolar I Disorder and Schizophrenia
TL;DR: Only schizophrenic subjects showed lower premorbid IQ, suggesting that they, but not the bipolar patients or either relative group, had suffered neurodevelopmental impairment, but both groups of patients had comparably poor current general intellectual levels, implying that some common pathogenic process operates once illness has begun.
Journal ArticleDOI
Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study.
Paolo Fusar-Poli,Paolo Fusar-Poli,Matthew R. Broome,Matthew R. Broome,Pall Matthiasson,Steven Williams,Michael Brammer,Philip McGuire +7 more
TL;DR: The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions, which need to be considered when interpreting group differences in activation between medicated patients and controls.
Journal ArticleDOI
Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature
TL;DR: Routine clinical inquiry about childhood maltreatment should be adopted within mental health settings and has potentially important treatment implications for identifying those individuals at elevated risk of functional disability.
Book ChapterDOI
Immunity and schizophrenia: autoimmunity, cytokines, and immune responses.
TL;DR: There is abundant evidence in schizophrenia of mutual dysregulation of neuronal function and immune system activity, and a pattern emerges suggesting aspects of immune activity being involved in the pathology of neuronal development that characterizes schizophrenia.
Journal ArticleDOI
Prediction and prevention of transition to psychosis in young people at incipient risk for schizophrenia.
Lisa J. Phillips,Alison R. Yung,Hok Pan Yuen,Christos Pantelis,Christos Pantelis,Patrick D. McGorry +5 more
TL;DR: A review of work that has been conducted at the PACE Clinic in Melbourne, Australia since 1994 is provided to develop strategies for the identification of young people at high risk of developing a psychotic disorder within a short period of time.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.