Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Premorbid intra-individual variability in intellectual performance and risk for schizophrenia: A population-based study
Abraham Reichenberg,Mark Weiser,Michael A. Rapp,Jonathan Rabinowitz,Asaf Caspi,James Schmeidler,Haim Y. Knobler,Gad Lubin,Daniela Nahon,Philip D. Harvey,Michael Davidson,Michael Davidson +11 more
TL;DR: Despite within-normal-range premorbid IQ, apparently healthy adolescents who will later on manifest schizophrenia, nevertheless have cognitive abnormalities such as increased variability across intellectual tasks, possibly related to frontal lobe abnormalities.
Journal ArticleDOI
Prenatal ontogeny as a susceptibility period for cortical GABA neuron disturbances in schizophrenia.
David W. Volk,David A. Lewis +1 more
TL;DR: This work considers a consideration of evidence that genetic and/or environmental insults that occur during gestation initiate a pathogenetic process that alters cortical GABA neuron ontogeny and produces the pattern of GABA neuron abnormalities, and consequently cognitive difficulties, seen in schizophrenia.
Journal ArticleDOI
Reciprocal causation models of cognitive vs volumetric cerebral intermediate phenotypes for schizophrenia in a pan-European twin cohort
Timothea Toulopoulou,Timothea Toulopoulou,N.E.M. van Haren,Xuan Zhang,Pak C. Sham,Stacey S. Cherny,Desmond Campbell,Marco Picchioni,Robin M. Murray,Dorret I. Boomsma,Hilleke E. Hulshoff Pol,Rachel M. Brouwer,Hugo G. Schnack,Lourdes Fañanás,Lourdes Fañanás,H. Sauer,Igor Nenadic,Matthias Weisbrod,Tyrone D. Cannon,René S. Kahn +19 more
TL;DR: This is the first study to demonstrate that schizophrenia liability is expressed partially through cognitive deficits, and one prediction of the finding that BV changes lie downstream of the disease liability is that the risk loci that influence schizophrenia liability will thereafter influence BV and to a lesser extent.
Journal ArticleDOI
NEURODEVELOPMENTAL AND NEUROPROGRESSIVE PROCESSES IN SCHIZOPHRENIA: Antithetical or Complementary, Over a Lifetime Trajectory of Disease?
John L. Waddington,John L. Waddington,A. Lane,Paul Scully,Conall Larkin,Conall Larkin,Eadbhard O'Callaghan +6 more
TL;DR: This article critically reviews the preponderance of evidence for each model of schizophrenia and provides an account of how these may interact or synergize to produce the characteristic clinical expression of schizophrenia.
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The relationship of early premorbid adjustment with negative symptoms and cognitive functions in first-episode schizophrenia: A prospective three-year follow-up study
Wing Chung Chang,Jennifer Y.M. Tang,Christy L.M. Hui,Gloria H.Y. Wong,Sherry Kit Wa Chan,Edwin Ho Ming Lee,Eric Y.H. Chen +6 more
TL;DR: In a Chinese cohort of first-episode schizophrenia-spectrum disorder, sub-components of early premorbid adjustment were shown to be differentially related to clinical and cognitive measures, highlighting the importance of applying a more refined delineation ofPremorbid functioning in studying illness outcome.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.