Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Evidence of a dose-response relationship between urbanicity during upbringing and schizophrenia risk
TL;DR: Continuous, or repeated, exposures during upbringing that occur more frequently in urbanized areas may be responsible for the association between urbanization and schizophrenia risk.
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Schizophrenia, “Just the Facts”: What we know in 2008: Part 1: Overview
TL;DR: A body of seventy-seven representative major findings is compiled and group them in terms of their specific relevance to schizophrenia -- etiologies, pathophysiology, clinical manifestations, and treatments, and pose one or more critical questions with reference to each "fact", which might help better elucidate the meaning of that finding for the authors' understanding of schizophrenia.
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Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms
Nancy C. Andreasen,Peg Nopoulos,Peg Nopoulos,Daniel S. O'Leary,Del D. Miller,Del D. Miller,Thomas H. Wassink,Thomas H. Wassink,Michael Flaum,Michael Flaum +9 more
TL;DR: It is proposed that schizophrenia may be a single disorder linked by a common pathophysiology (a neurodevelopmental mechanism), which leads to a misconnection syndrome of neural circuitry.
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Premorbid IQ in schizophrenia: a meta-analytic review.
TL;DR: Overall, schizophrenia samples demonstrated a reliable, medium-sized impairment in premorbid IQ, and all studies with pre- and post-onset testing within the same sample suggested that a significant decline in the IQ of individuals with schizophrenia, relative to comparison subjects, was associated with the onset of frank psychosis.
References
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Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
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Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.