Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Marital and Labor Market Status in the Long Run in Schizophrenia
TL;DR: For individuals with schizophrenia, the odds ratios of being unmarried or not being fully employed were significantly increased even 25 years after admission, and this pattern was especially pronounced for men and for individuals who had more admissions.
Journal ArticleDOI
Violent behaviour among people with schizophrenia: a framework for investigations of causes, and effective treatment, and prevention.
TL;DR: It is hypothesized that among violent offenders with schizophrenia there are three distinct types defined by the age of onset of antisocial and violent behaviour, which emerges in childhood or early adolescence, well before illness onset, and that remains stable across the lifespan.
Journal ArticleDOI
Risk Factors for Psychosis: Impaired Social and Role Functioning
Barbara A. Cornblatt,Ricardo E. Carrión,Jean Addington,Larry J. Seidman,Larry J. Seidman,Elaine F. Walker,Tyronne D. Cannon,Kristin S. Cadenhead,Thomas H. McGlashan,Diana O. Perkins,Ming T. Tsuang,Ming T. Tsuang,Scott W. Woods,Robert K. Heinssen,Todd Lencz,Todd Lencz +15 more
TL;DR: Early impaired social functioning appears to be a risk factor for psychosis and, added to APS, could potentially contribute to accurate identification of CHR individuals and provide a new direction for early intervention to reduce long-term disability.
Journal ArticleDOI
White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis.
Katherine H. Karlsgodt,Katherine H. Karlsgodt,Tara A. Niendam,Carrie E. Bearden,Tyrone D. Cannon +4 more
TL;DR: The findings indicate thatwhite matter development may be altered in youth at risk for psychosis, possibly due to disrupted developmental mechanisms, and further, that white matter integrity may be predictive of functional outcome.
Journal ArticleDOI
Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia.
TL;DR: Negative symptoms and other nonspecific behavioral abnormalities represent clinically important phenomena in prodromal patients, and may provide insight into pathophysiologic mechanisms in schizophrenia and possible preventive interventions.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.