Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Dissertation
A qualitative study of emotional experiences during the pre-psychotic period
TL;DR: Overall, the PPP was characterised by an increase in distress over time, including experiences of derealisation and the environment feeling different; anxiety and confusion and a drive to find and explanation for the changes that were being experienced; and a sense of apprehension that something significant was about to happen.
Book ChapterDOI
Continua or Classes? Vexed Questions on the Latent Structure of Schizophrenia
TL;DR: The focus here is on this latter sense of continuum, which concerns the latent structure of the population and the nature of the signs or symptoms of the disorder and their relationships to normal psychological experience.
Journal ArticleDOI
Targeting synaptic plasticity in schizophrenia: insights from genomic studies.
Arne W. Mould,Arne W. Mould,Nicola A. L. Hall,Nicola A. L. Hall,Ira Milosevic,Elizabeth M. Tunbridge,Elizabeth M. Tunbridge +6 more
TL;DR: In this article, a new information is emerging from genomic findings, which converge on synaptic plasticity and provide a new window on the neurobiology of schizophrenia, and Translating this information into therapeutic advances will require a multidisciplinary and collaborative approach.
Dissertation
A randomised controlled trial of medication management training for CPNs
TL;DR: It was hypothesised that medication management training would lead to clinically significant improvements in patients' psychopathology, as a result of enhanced treatment compliance, compared to routine care at week 26 assessment, and a randomised controlled trial was conducted.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.