Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Psychopathologie à l'adolescence et scolarité : le concept soins-études : une approche singulière des établissements de la Fondation Santé des Étudiants de France
TL;DR: In this paper, a parallele entre le temps du developpement psychologique de l'adolescent and celui scolaire, nous avons decrit un "cercle vicieux" mettant en evidence un effet de conjugaison et de renforcement mutuel entre les difficultes scolaires and les troubles psychopathologiques, dans la perspective of mettre en evidence that l'apport de la scolarite ne se limite pas a un role d'integration.
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Does maternal psychopathology discriminate between children with DSM-IV generalised anxiety disorder or oppositional defiant disorder? The predictive validity of maternal axis I and axis II psychopathology
TL;DR: The results demonstrated that maternal symptomatic and personality psychopathology was differentially related to childhood anxiety or behavioural disorders, whereas mothers of children with GAD seemed to be more somatic preoccupied, controlling and over-protective.
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Association Between Lifetime Affective Symptoms and Premature Mortality.
Gemma Archer,Gemma Archer,Diana Kuh,Matthew Hotopf,Matthew Hotopf,Mai Stafford,Marcus Richards +6 more
TL;DR: Future research into causal pathways and potential points of intervention for premature mortality should consider affective symptom history, as associations were largely explained by factors in adulthood.
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Personality disorders in first-episode psychosis
Erik Simonsen,Ulrik Haahr,Erik Lykke Mortensen,Svein Friis,Jan Olav Johannessen,Tor K. Larsen,Ingrid Melle,Stein Opjordsmoen,Bjørn Rishovd Rund,Thomas H. McGlashan,Per Vaglum +10 more
TL;DR: The schizoid and the avoidant were the most frequent personality disorders and both were associated with social withdrawal during childhood and adolescence.
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Neural Correlates of Enhanced Genetic Risk for Schizophrenia
TL;DR: It is concluded that deficits are apparent in relatives of affected individuals that are similar to but less marked than those seen in patients with schizophrenia.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.