Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Violence of Young Criminals Predicts Schizophrenia: A 9-Year Register-Based Followup of 15- to 19-Year-Old Criminals
TL;DR: Conviction of violence in late adolescence was significantly associated with future diagnosis of schizophrenia, and violent behavior can be seen as part of the preschizophrenia phase of young criminals.
Journal ArticleDOI
Cumulative effect of anatomical risk factors for schizophrenia : An MRI study
Christiana M. Leonard,John M. Kuldau,Joshua I. Breier,Paula Zuffante,Erin R. Gautier,Dawn Christy Heron,Elise M. Lavery,Jennifer Packing,Sharyl Williams,Cheryl A. Debose +9 more
TL;DR: This is the first study to demonstrate that schizophrenics can be distinguished from matched controls on the basis of brain anatomy alone, and the risk of schizophrenia may depend on the total amount of neural deviance, rather than on anomalies in a single structure or circuit.
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Neurocognitive performance in children aged 9-12 years who present putative antecedents of schizophrenia.
Alexis E. Cullen,Hannah Dickson,Sophie West,Robin G. Morris,Glenn L. Mould,Sheilagh Hodgins,Robin M. Murray,Kristin R. Laurens,Kristin R. Laurens +8 more
TL;DR: Children aged 9-12 years who present multiple antecedents of schizophrenia display poorer neurocognition than healthy peers on several domains showing pronounced deficits in schizophrenia, first-episode psychosis, and youth with prodromal symptoms.
Journal ArticleDOI
Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in young rats: a possible correlation with the development of schizophrenia-like deficits.
TL;DR: Whether or not EC disruption during prenatal development is able to affect behavior, including memory and learning, and brain nerve growth factor (NGF), and the possibility that these behavioral and biochemical alterations might be associated with the onset of SZ is discussed.
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Fine motor function and neuropsychological deficits in individuals at risk for schizophrenia.
Ute Gschwandtner,Marlon Pflüger,Jacqueline Aston,Stefan Borgwardt,M. Drewe,Rolf-Dieter Stieglitz,Anita Riecher-Rössler +6 more
TL;DR: The combined evaluation of the two test batteries separates the two groups into individuals at risk and healthy controls better than each test battery alone, and might therefore be a valuable contribution to detecting beginning schizophrenia.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.