Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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PPARα Signaling: A Candidate Target in Psychiatric Disorder Management
TL;DR: Based on robust preclinical evidence and the initial results of clinical studies, future clinical trials should assess the efficacy of PPARα agonists in the treatment of mood and neurodevelopmental disorders, such as depression, schizophrenia, and ASD.
Dissertation
Cognition, psychopathology and the role of genetic variation in Catechol-O-Methyltransferase in children at increased risk of schizophrenia
TL;DR: The findings showed that COMT was indirectly associated with PEs through processing speed, IQ and attention, and it was found that using different research designs to investigate specific aims in samples at increased risk enables the researcher to widen their scope of interpretation.
Journal ArticleDOI
“If you’re not safe anywhere, you turn it inside yourself”: Narratives about childhood experiences told by 12 individuals diagnosed with psychosis
Jennifer Strand,Inga Tidefors +1 more
TL;DR: It could be questioned whether what are commonly viewed as early symptoms of schizophrenia might instead be the child’s attempts to adapt, in order to survive in a disorganized family.
Journal ArticleDOI
Advances in the genetics of schizophrenia: will high-risk copy number variants be useful in clinical genetics or diagnostics?
David A. Collier,Evangelos Vassos,Simon Holden,Christine Patch,Philip McGuire,Cathryn M. Lewis +5 more
TL;DR: In this paper, the authors assess whether these "high risk" pathogenic copy number variants might be useful in a clinical genetic or diagnostic setting and conclude that there is also insufficient evidence in relation to schizophrenia to suggest that clear clinical benefit would be gained from learning one's genetic status pre-symptomatically.
Schizotypy: Consideration of neurological soft signs, language and affective factors
TL;DR: A comparison of clinical and non-clinical hallucinations in adult populations and the importance of the schizotypal personality trait in adults with schizophrenia and their relatives shows that language processing abnormalities in patients with schizophrenia are linked to hallucinations.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.