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Journal ArticleDOI

Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort

Peter B. Jones, +3 more
- 19 Nov 1994 - 
- Vol. 344, Iss: 8934, pp 1398-1402
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.
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This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.

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Citations
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The relationship between psychotic-like symptoms and neurocognitive performance in a general adolescent psychiatric sample

TL;DR: Both positive, psychotic-like symptoms and negative symptoms are associated with lower levels of neurocognitive functioning among adolescents in psychiatric treatment regardless of whether CHR criteria are met, and clinical high-risk status is associated with impaired visuospatial task performance.
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Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.

Maria Jalbrzikowski, +136 more
- 01 Jul 2021 - 
TL;DR: In a case-control study, baseline T1-weighted magnetic resonance imaging (MRI) data were pooled from 31 international sites participating in the ENIGMA Clinical High Risk for Psychosis Working Group as discussed by the authors.
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The association between cognition and functional outcome in first-episode patients with schizophrenia : mystery resolved?

TL;DR: The presence of a prospective association between cognition and functional outcome in first episode patients with schizophrenia is much debated and an attempt is made to investigate this association in patients with paranoid schizophrenia.
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Psychoanalysis and schizophrenia: A cautionary tale

TL;DR: For illnesses such as borderline conditions and various severe character disorders for which biological factors are still much in doubt, analysts are today proposing etiological formulations similar to those once advanced for schizophrenia, which may indeed prove correct for these disturbances, but analysts are urged to heed the cautionary tale of psychoanalysis and schizophrenia.
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1-year follow-up study of cognitive function in first-episode non-affective psychosis

TL;DR: Patients' deficits remained stable over time in all cognitive domains except Verbal Memory, in which less performance improvement was found, and patients' cognitive performance improved in virtually all the cognitive domains after one year.
References
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Journal ArticleDOI

Implications of normal brain development for the pathogenesis of schizophrenia

TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book

The strategy of preventive medicine

Geoffrey Rose
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
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Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic

TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.

TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI

Is schizophrenia a neurodevelopmental disorder

Robin M. Murray, +1 more
- 19 Sep 1987 - 
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.
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