Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Early intervention in psychosis: still the 'best buy'?
David J. Castle,Swaran P. Singh +1 more
TL;DR: In this debate David Castle questions whether separate early intervention services are the best option and argues instead for an integrated approach, and Swaran Singh responds, robustly defending the value ofEarly intervention services.
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Growth in Young Adults Who Screen Positive for Non-Affective Psychosis: Birth Cohort Study:
TL;DR: Unlike developmental behavioural problems, which showed continuity from childhood through adolescence, SP-NAP was not associated with marked deviations in growth trajectory for male subjects, but the present data suggests that female subjects with SP-nAP had an altered skeletal growth trajectory.
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Poor premorbid school performance is associated with later cigarette smoking among schizophrenia patients.
Kaisa Riala,Helinä Hakko,Matti Isohanni,Jari Jokelainen,Jari Jokelainen,Mark Weiser,Pirkko Räsänen +6 more
TL;DR: Poor school performance might represent premorbid nicotinergic dysfunction associated with cognitive deficits in future smokers among schizophrenia patients compared with those who remained non-smokers.
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Early manifestations of behavioral disorders in children and adolescents
TL;DR: Rio et al. as discussed by the authors discuss the early diagnosis of behavioral disorders in childhood and adolescence and to provide the pediatrician with practical knowledge about the first symptoms of the main behavioral disorders at this age.
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Cognitive impairment from early to middle adulthood in patients with affective and nonaffective psychotic disorders
Josephine Mollon,Samuel R. Mathias,Emma Knowles,Amanda L. Rodrigue,Marinka M.G. Koenis,Godfrey D. Pearlson,Abraham Reichenberg,Jennifer Barrett,Dominique Denbow,Katrina Aberizk,Molly Zatony,Russell A. Poldrack,John Blangero,David C. Glahn +13 more
TL;DR: Comparisons of cognitive functioning between controls and psychosis groups throughout early and middle adulthood suggest similarities, but also differences in the profile of cognitive dysfunction in adults with affective and nonaffective psychotic disorders.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.