Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Long-term affective disorder in people with mild learning disability
Marcus Richards,Barbara Maughan,Rebecca Hardy,Ian P. Hall,Andre Strydom,Michael E. J. Wadsworth +5 more
TL;DR: Learning disability is strongly associated with risk of affective disorder, persisting well into midlife, not accounted for by social and material disadvantage or by medical disorder.
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Association between nonpsychotic psychiatric diagnoses in adolescent males and subsequent onset of schizophrenia.
Mark Weiser,Araham Reichenberg,Jonathan Rabinowitz,Zeev Kaplan,Mordehai Mark,Ehud Bodner,Daniella Nahon,Michael H. Davidson +7 more
TL;DR: These results reflect the relatively common finding of impaired functioning in patients later hospitalized for schizophrenia and the relatively low power of these disorders in predicting schizophrenia.
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Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders
TL;DR: It is proposed that alterations of a distinct set of multiple, noncontiguous genes encoded in this chromosomal region, in concert with modulatory impacts of genetic background and environmental factors, variably shift the probabilities of phenotypes along a predetermined developmental trajectory.
Journal ArticleDOI
Dimensions of depression, mania and psychosis in the general population
Lydia Krabbendam,Inez Myin-Germeys,R. de Graaf,Wilma A. M. Vollebergh,Willem A. Nolen,J. Iedema,J. van Os +6 more
TL;DR: In the general population, seven correlated but separable dimensions of experiences exist that resemble dimensions of psychopathology seen in clinical samples with severe mental illness.
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Infant developmental milestones: a 31-year follow-up
TL;DR: Those who develop faster during their first year of life tend to attain higher levels of education in adolescence and adulthood, and those who reach infant developmental milestones sooner have significantly better mean scores in teacher ratings.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.