Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Incidence and Cumulative Risk of Treated Schizophrenia in the Prenatal Determinants of Schizophrenia Study
Michaeline Bresnahan,Alan Brown,Catherine Schaefer,Melissa D. Begg,Richard Jed Wyatt,Ezra Susser +5 more
TL;DR: Age- and sex-specific estimates of incidence and cumulative risk for DSM-IV schizophrenia were higher than those in traditional incidence studies but similar to recent findings in other cohorts.
Journal ArticleDOI
Enuresis as a premorbid developmental marker of schizophrenia.
Thomas M. Hyde,Amy Deep-Soboslay,Bianca Iglesias,Joseph H. Callicott,James M. Gold,Andreas Meyer-Lindenberg,Robyn A. Honea,Llewellyn B. Bigelow,Michael F. Egan,Esther M. Emsellem,Daniel R. Weinberger +10 more
TL;DR: The high frequency of childhood enuresis associated with SCZ and abnormalities in prefrontal function and structure in patients with a childhood history of enures is suggested to be a premorbid marker for neurodevelopmental abnormalities related to SCZ, adding to the evidence implicating prefrontal dysmaturation in this disorder.
Journal ArticleDOI
Postnatal development of tyrosine hydroxylase- and dopamine transporter-immunoreactive axons in monkey rostral entorhinal cortex.
TL;DR: Investigating the postnatal development of dopamine axons in the rostral subdivision of macaque monkey entorhinal cortex suggests that developmental changes in the dopamine innervation of cortical regions may parallel the functional maturation of those areas.
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Burden, risk factors, and comorbidities of behavioural and emotional problems in Kenyan children: a population-based study.
Symon M. Kariuki,Amina Abubakar,Amina Abubakar,Amina Abubakar,Martha Kombe,Michael Kazungu,Rachael Odhiambo,Alan Stein,Charles R. Newton,Charles R. Newton,Charles R. Newton +10 more
TL;DR: Behavioural and emotional problems and associated comorbidities should be identified and addressed in young children in this Kenyan rural area and are associated with preventable risk factors.
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Early motor development is abnormal in complexin 1 knockout mice.
TL;DR: A role for complexin I depletion should be considered in diseases where deficits in early sensory and motor development exist, such as autism and schizophrenia, according to this evaluation of Cplx1(-/-) mice.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.