Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Control of cortex development by ULK4, a rare risk gene for mental disorders including schizophrenia
Bing Lang,Bing Lang,Lei Zhang,Guan-Yu Jiang,Guan-Yu Jiang,Ling Hu,Ling Hu,Wei Lan,Wei Lan,Lei Zhao,Irene Hunter,Michal Pruski,Michal Pruski,Ning-Ning Song,Ying Huang,Ling Zhang,David St Clair,Colin D. McCaig,Yu-Qiang Ding +18 more
TL;DR: It is concluded that Ulk4 plays an essential role in normal brain development and when defective, the risk of neurodevelopmental disorders such as schizophrenia is increased.
Journal ArticleDOI
Familiality of clinical characteristics in schizophrenia.
Harvey Wickham,Cathy Walsh,Philip Asherson,Michael Gill,Michael John Owen,Peter McGuffin,Robin M. Murray,Pak C. Sham +7 more
TL;DR: Age of onset, course of disorder, impairment during disorder, mode of onset and premorbid functioning were shown to be familial and supports their use in the delineation of homogeneous subsets for future genetic studies.
Book
Biological Child Psychiatry: Recent Trends and Developments
TL;DR: This publication is of valuable reading for child psychiatrists, child psychologists, pediatricians and any mental health professionals working with children and adolescents to update their knowledge in this exciting and new area which is extremely important for implementing contemporary and evidence based treatments for individuals in this age range.
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Neurodevelopmental Schizophrenia: Obstetric Complications, Birth Weight, Premorbid Social Withdrawal and Learning Disabilities
TL;DR: The findings seem to confirm the concept of schizophrenia as a neurodevelopmental process and show significant differences in OCs, birth weight, premorbid social and learning functioning between patients and their same-sex, healthy siblings.
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IQ scores of treatment-resistant schizophrenia patients before and after the onset of the illness.
Brian Sheitman,Michael G. Murray,Jennifer A. Snyder,Susan G. Silva,Robert Goldman,Robert Goldman,Miranda Chakos,Jan Volavka,Jan Volavka,Jeffrey A. Lieberman +9 more
TL;DR: The correlations of actual and estimated pre-morbid IQ scores and estimated current IQ scores in 27 treatment-resistant schizophrenia patients suggest that pre-Morbid IQ test scores are highly predictive of post- Morbid scores.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.