Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Impairments in cognition across the spectrum of psychiatric disorders: evidence from a Swedish conscript cohort
TL;DR: It was found that reduced intellectual functioning was found in association with psychosis and neurotic disorders including depression, personality disorders, alcoholism, and drug dependence.
Journal ArticleDOI
Risk factors and the prevalence of neurosis and psychosis in ethnic groups in Great Britain.
TL;DR: The excess of psychosis in Africans and Afro-Caribbeans in Great Britain appears to be partly explained by socio-economic disadvantage, but larger studies are needed to confirm this.
Journal ArticleDOI
Anxiety and the schizophrenic process: clinical and epidemiological evidence
G. Turnbull,Paul Bebbington +1 more
TL;DR: There is a significant link between anxiety and schizophrenia, and this may represent a psychological process integral to an appreciable number of cases of schizophrenia.
Journal ArticleDOI
Seasonality and infectious disease in schizophrenia: the birth hypothesis revisited.
TL;DR: This study replicated and expanded previous studies by examining seasonal and infectious disease influences on schizophrenia prevalence by using one of the largest sample of schizophrenic individuals in the literature to date and indicated a significant relationship between winter season and schizophrenia incidence.
Journal ArticleDOI
Cluster analysis of cognitive deficits may mark heterogeneity in schizophrenia in terms of outcome and response to treatment
Elsa Gilbert,Chantal Mérette,Valérie Jomphe,Claudia Émond,Nancie Rouleau,Roch-Hugo Bouchard,Marc-André Roy,Thomas Paccalet,Michel Maziade +8 more
TL;DR: Cognitive impairments are central to schizophrenia, but their clinical utility for tagging heterogeneity in lifetime outcome and response to treatment is not conclusive, and patients with selective cognitive impairments demonstrated better improvement at outcome, whereas the generally impaired patients were more likely to be treatment refractory.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.