Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Epigenetic predictors of psychotic symptoms in adolescence
TL;DR: The findings suggest that exposure to influenza and/or diabetes/glycosuria during gestation may predispose an individual to the later development of psychotic symptoms via altered expression of specific genes involved in early brain development.
Journal ArticleDOI
Memory and schizophrenia.
TL;DR: The underlying framework of both the review and that of Dr Danion and colleagues is that episodic memory is not a simple construct but, instead, encompasses multiple cognitive processes and future studies on memory and schizophrenia will greatly benefit from developments in the field of cognitive psychology and cognitive neuroscience.
Journal ArticleDOI
Neonatal Hippocampal Damage in the Rat: A Heuristic Model of Schizophrenia
Book ChapterDOI
Introduction to schizophrenia
TL;DR: Schizophrenia is a complex disorder that affects virtually all domains of mental function, including perception, thought, emotion, will, judgement and execution of voluntary motor action.
Book ChapterDOI
Neurodevelopment and Schizophrenia: Is there a role for social factors in a comprehensive development model for schizophrenia?
TL;DR: This article reviewed the social factors that are postulated to operate early in life and those which may act more proximal to the onset of the disorder, and found that individuals with schizophrenia and individuals with genetic susceptibility to schizophrenia display greater levels of emotional reactivity to small daily life stressors than do control subjects.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.