Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Impaired reading comprehension and mathematical abilities in male adolescents with average or above general intellectual abilities are associated with comorbid and future psychopathology.
Mark Weiser,Abraham Reichenberg,Jonathan Rabinowitz,Daniella Nahon,Efrat Kravitz,Gad Lubin,Haim Y. Knobler,Michael H. Davidson,Shlomo Noy +8 more
TL;DR: The results support screening male adolescents with learning disorders for psychopathology and suggest that impairments in intellectual functioning and abnormal behaviors leading to mental illnesses may share common neurobiological substrates.
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Perinatal complications and schizophrenia: involvement of the immune system.
TL;DR: It is suggested that, at least in part, events occurring within the intrauterine or perinatal environment at critical times of brain development underlies emergence of the psychosis observed during adulthood, and brain pathologies that are hypothesized to be from birth.
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A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients.
TL;DR: Amantadine improved visuomotor coordination independently of extrapyramidal side-effects but not cognitive function, and the mechanism is more likely to involve glutaminergic NMDA than dopaminergic mechanisms.
Journal ArticleDOI
Response activation impairments in schizophrenia: Evidence from the lateralized readiness potential
Emily S. Kappenman,Samuel T. Kaiser,Benjamin M. Robinson,Sarah E. Morris,Britta Hahn,Valerie M. Beck,Carly J. Leonard,James M. Gold,Steven J. Luck +8 more
TL;DR: In both experiments, the patient LRP was reduced as much under conditions of low response competition as under high competition, which is incompatible with a failure of patients to suppress competition and consistent with a deficit in activating the correct response.
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Searching for Susceptibility Genes in Schizophrenia
TL;DR: Most candidate gene studies have been based upon neuropharmacological studies suggesting that abnormalities in monoamine neurotransmission play a role in the aetiology of schizophrenia, but overall, the results have been disappointing.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.