Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Schizophrenia and the Myth of Intellectual Decline
TL;DR: The deficit in intellectual function observed in patients with schizophrenia who had attended a child psychiatry service where measurement of intelligence was routine is lifelong and predates the onset of schizophrenia.
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Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia
Alan S. Brown,Teodoro Bottiglieri,Catherine Schaefer,Charles P. Quesenberry,Liyan Liu,Michaeline Bresnahan,Ezra Susser +6 more
TL;DR: Findings indicate that elevated third-trimester homocysteine levels may be a risk factor for schizophrenia, and the use of folic acid supplementation would merit evaluation as a strategy for prevention of schizophrenia in offspring.
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Edinburgh high risk study--findings after four years: demographic, attainment and psychopathological issues.
Eve C. Johnstone,Suheib S. Abukmeil,Majella Byrne,R. Clafferty,Elizabeth Grant,A. Hodges,Stephen M. Lawrie,D. G. C. Owens +7 more
TL;DR: Comparisons of the high risk subjects, well controls and subjects with first-episode schizophrenia in terms of demographic, childhood, psychopathological, educational and employment, forensic and social work variables are presented.
Journal ArticleDOI
Assessing cognitive function in clinical trials of schizophrenia
Jennifer H. Barnett,Trevor W. Robbins,Verity C. Leeson,Barbara J. Sahakian,Eileen M. Joyce,Andrew D. Blackwell +5 more
TL;DR: The utility of CANTAB according to MATRICS and CNTRICS recommendations is reviewed and computerised cognitive assessment may optimise the statistical power of cognitive trials by reducing measurement error and between-site variability and decreasing patient attrition through increased tolerability.
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Childhood Neuromotor Dysfunction in Schizophrenia Patients and Their Unaffected Siblings: A Prospective Cohort Study
Isabelle M. Rosso,Carrie E. Bearden,Hollister Jm,Timothy L. Gasperoni,Sanchez Le,Trevor R. Hadley,Tyrone D. Cannon +6 more
TL;DR: Deviance on motor coordination measures at 7 years was associated with both adult schizophrenia and unaffected sibling status, suggesting that a cofamilial (and perhaps genetic) factor underlies motor coordination deficits in schizophrenia.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.