Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Cognition, schizophrenia, and the atypical antipsychotic drugs
TL;DR: Recognition of the central importance of cognitive impairment to schizophrenia further diminished in the 1950s, after the development of antipsychotic drugs which had the ability to improve delusions and hallucinations, although, at the same time, causing significant extrapyramidal side effects (EPS).
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Infant Developmental Milestones and Subsequent Cognitive Function
TL;DR: It is hypothesized that earlier attainment of developmental milestones would be associated with better subsequent intellectual performance throughout the range of abilities, rather than confined to extremes.
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Treatment of the schizophrenia prodrome: is it presently ethical?
TL;DR: It is argued that interest in prevention has outpaced the necessary scientific and ethical underpinnings for clinical trials involving the schizophrenia prodrome and that it is essential to establish solid base rates for schizophrenia in prodromal individuals before early treatment can be effectively evaluated.
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People at risk of schizophrenia. Sample characteristics of the first 100 cases in the Edinburgh High-Risk Study.
TL;DR: Some significant differences emerged between the high-risk group and the control group, namely in previous psychiatric history, forensic contacts, and delinquent behaviour, which may represent increased risk of developing schizophrenia.
Journal ArticleDOI
The psychology of persecutory ideation II: a virtual reality experimental study.
Daniel Freeman,Philippa Garety,Paul Bebbington,Mel Slater,Elizabeth Kuipers,David Fowler,Catherine M. Green,Joel Jordan,Katarzyna Ray,Graham Dunn +9 more
TL;DR: It is concluded that nonclinical paranoid thoughts are most closely associated with emotional disturbances and anomalous experiences and Extreme reasoning bias may particularly contribute to the development of clinical phenomena.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.