Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Gene x environment interactions in schizophrenia and bipolar disorder: evidence from neuroimaging.
TL;DR: A systematic review on the neuroimaging studies exploring GxE interactions relative to SZ or BD finds that genetic risk and environmental exposures such as cannabis or obstetrical complications seem to interact leading to specific neuroim imaging cerebral alterations in SZ.
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Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder
Michel Maziade,Nathalie Gingras,Nancie Rouleau,S. Poulin,Valérie Jomphe,Marie-Eve Paradis,Chantal Mérette,Marc-André Roy +7 more
TL;DR: The follow-up since 1989 of a large sample of multigenerational families of eastern Québec that are densely affected by schizophrenia or bipolar disorder has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent and of a BP parent who had an extremely loaded family history.
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Developmental precursors and biological markers for schizophrenia and affective disorders: specificity and public health implications.
Peter B. Jones,C. J. Tarrant +1 more
TL;DR: The specificity of some developmental precursors to schizophrenia as an outcome is discussed, with particular reference to longitudinal birth cohort studies, and underlying structural brain abnormalities are considered.
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A lack of cerebral lateralization in schizophrenia is within the normal variation in brain maturation but indicates late, slow maturation
TL;DR: It is suggested that in the past environmental challenges have favored early maturation, with its abundant neuronal population, arborization and excessive density of synapses and cerebral excitability which has powered evolution through the mechanism of natural selection.
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Abnormal movements are associated with poor psychosocial functioning in adolescents at high risk for psychosis
Vijay A. Mittal,Maria Jalbrzikowski,Melita Daley,Cristina Roman,Carrie E. Bearden,Tyrone D. Cannon +5 more
TL;DR: Movement abnormalities are closely associated with deficits in psychosocial functioning and the link between these phenomena may serve to refine etiological models of frontal-subcortical circuit dysfunction and inform understanding of functioning and outcome of these affected youth.
References
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Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.