Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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BookDOI
Neural Development and Schizophrenia
TL;DR: The capability of influenza viruses to elicit autoimmune reactions to brain tissue in man and animals, and the proven causative role of maternal autoantibodies in various disease-states of the fetus and neonate suggest a new interpretation of the immunological data.
Journal ArticleDOI
Imaging as a tool in exploring the neurodevelopment and genetics of schizophrenia
Sophia Frangou,Robin M. Murray +1 more
TL;DR: Findings support the idea that schizophrenia is a developmental rather than a degenerative condition and involvement of the genes controlling neurodevelopment.
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Genetic Risk for Schizophrenia, Obstetric Complications, and Adolescent School Outcome: Evidence for Gene-Environment Interaction
Jennifer K. Forsyth,Lauren M. Ellman,Antti Tanskanen,Antti Tanskanen,Ulla Mustonen,Matti O. Huttunen,Jaana Suvisaari,Tyrone D. Cannon +7 more
TL;DR: In this paper, the authors examined the relationship between low birth weight and hypoxia on school outcome at age 15-16 years in a Finnish sample of 1070 offspring at LR and 373 offspring at HR for schizophrenia, based on parental psychiatric history.
Journal ArticleDOI
Interaction of neurodevelopmental pathways and synaptic plasticity in mental retardation, autism spectrum disorder and schizophrenia: Implications for psychiatry
TL;DR: An integrated view on MR, ASD and SCZ for child & adolescent and adult psychiatry in pathophysiology and research perspectives proposes a continuum of genetic risk factors impacting on synaptic plasticity with MR causing impairments in global cognitive abilities, ASD in social cognition andSCZ in both global and social cognition.
Journal ArticleDOI
Neonatal hyperbilirubinaemia--a vulnerability factor for mental disorder?
C. Dalman,J. Cullberg +1 more
TL;DR: In this paper, a total of 509 children with NHB (bilirubin > 15 mg %) were compared with the same number of controls with respect to in-patient psychiatric care during 1971-1993.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.