Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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A Prospective Cohort Study of Childhood Behavioral Deviance and Language Abnormalities as Predictors of Adult Schizophrenia
Carrie E. Bearden,Isabelle M. Rosso,Hollister Jm,Sanchez Le,Trevor R. Hadley,Tyrone D. Cannon +5 more
TL;DR: Unintelligible speech at age 7 was a highly significant predictor of adult schizophrenia, and poor expressive language ability predicted both schizophrenia and unaffected sibling outcome, and early behavioral and language dysfunction did not differentially characterize preschizophrenia subjects with a history of fetal hypoxia.
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Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: Preliminary studies
Matcheri S. Keshavan,Debra M. Montrose,Joseph N. Pierri,Elizabeth L. Dick,David R. Rosenberg,Lalith Talagala,John A. Sweeney +6 more
TL;DR: Preliminary data is provided from an ongoing study of neurobiological alterations in the offspring of schizophrenia patients that showed a trend for decreased NAA/choline ratios in the anterior cingulate region in the OS group as compared to HC subjects.
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Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders.
TL;DR: The amygdala is a common site for neuropathology in neurodevelopmental disorders and is therefore a potential target for therapeutics to alleviate associated symptoms and is assessed for amygdala dysregulation from postmortem studies, structural MRI analyses or functional MRI.
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Premorbid speech and language impairments in childhood-onset schizophrenia: association with risk factors.
Rob Nicolson,Marge Lenane,Sujatha Singaracharlu,Dolores Malaspina,Jay N. Giedd,Susan D. Hamburger,Peter Gochman,Jeffrey S. Bedwell,Gunvant K. Thaker,Thomas V. Fernandez,Marianne Wudarsky,Daniel W. Hommer,Judith L. Rapoport +12 more
TL;DR: The patients with premorbid speech and language impairments had higher familial loading scores for schizophrenia spectrum disorders and more obstetrical complications, and their relatives had worse smooth-pursuit eye movements.
References
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Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.