Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Risk for schizophrenia--broadening the concepts, pushing back the boundaries.
Mary Cannon,Mary Clarke +1 more
TL;DR: An overview of environmental risk factors for schizophrenia is given, which include prenatal infection, obstetric complications, childhood developmental impairments, early rearing environment, adolescent cannabis use, urban dwelling and membership of a minority population.
Journal ArticleDOI
The effects of neonatal lesions in the amygdala or ventral hippocampus on social behaviour later in life.
TL;DR: It is concluded that the amygdala is an important structure for social play behaviour and the effects on social behaviour that are dependent on the day of lesioning are an indication of a neurodevelopmental deficit of structures connected to the (medial part) of the AM.
Journal ArticleDOI
Motor Abnormalities: From Neurodevelopmental to Neurodegenerative Through “Functional” (Neuro)Psychiatric Disorders
Victor Peralta,Manuel J. Cuesta +1 more
TL;DR: MAs appear to represent a true transdiagnostic domain putatively sharing neurobiological mechanisms of neurodevelopmental, functional or neurodegenerative origin.
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Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses
Kristin R. Laurens,Luming Luo,Sandra Matheson,Vaughan J. Carr,Vaughan J. Carr,Alessandra Raudino,Felicity Harris,Melissa J. Green +7 more
TL;DR: Shared risk factors for SSD and AP may include obstetric complications, childhood psychopathology, cognitive markers and motor dysfunction, but the capacity to distinguish common versus distinct risk factors/antecedents for HDD and AP is limited by the scant availability of prospective data, and inconsistency in replication.
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Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry.
TL;DR: Clinical features, neurobiological and neuropsychological findings in childhood and adolescent onset schizophrenia including some results of studies of the author on age at onset, premorbid symptoms, treatment and course are reviewed.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.