Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Childhood growth and future development of psychotic disorder among Helsinki high-risk children
Laura T. Niemi,Jaana Suvisaari,Jaana Suvisaari,Jari Haukka,Jari Haukka,Jouko Lönnqvist,Jouko Lönnqvist +6 more
TL;DR: Catch-up growth increases the risk of schizophrenia among offspring of mothers with psychotic disorder, and the combination of being in the lowest tertile for ponderal index at birth but in the highest tertiles for BMI at 7 years predicted later development of schizophrenia.
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Prenatal exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice.
Lingling Lu,Takayoshi Mamiya,Ping Lu,Ping Lu,Kazuya Toriumi,Akihiro Mouri,Masayuki Hiramatsu,Hyoung-Chun Kim,Li Bo Zou,Taku Nagai,Toshitaka Nabeshima +10 more
TL;DR: Prenatal exposure to PCP produced long-lasting behavioural deficits, accompanied by the abnormal expression and dysfunction of NMDA receptors in postpubertal mice, which were attenuated by atypical antipsychotic treatment.
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Schizophrenias and epilepsies: why? when? how?
TL;DR: It would be wise to be very precise in describing the behaviors and the nature and timing of their emergence rather than using terms such as psychoses, now that it is possible to measure deficits in brain structure.
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Population-based registers in psychiatric research
TL;DR: It is concluded that case registers often offer an advantageous alternative to primarily collected data in terms of sample size, representativity, and the absence of recall bias, whereas a lack of relevant information for a particular study may detract from the usefulness of this type of data.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.