Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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IQ decline in cross-sectional studies of schizophrenia: methodology and interpretation.
TL;DR: Differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time, suggesting a prefrontal-dysexecutive syndrome.
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Infant motor development and adult cognitive functions in schizophrenia
Graham K. Murray,Graham K. Murray,Peter B. Jones,Kristiina Moilanen,Juha Veijola,Juha Veijola,Jouko Miettunen,Tyrone D. Cannon,Matti Isohanni +8 more
TL;DR: These findings are consistent with the hypothesis that in schizophrenia mild infant motor developmental delay and adult cognitive deficits are age dependent manifestations of the same underlying neural process and may be better considered as part of a single longitudinal syndrome.
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Health and development in the first 4 years of life in offspring of women with schizophrenia and affective psychoses: Well-Baby Clinic information
TL;DR: The results suggest a limited overlap in the diathesis characteristics associated with risk for Sc vs. Aff psychosis, and the importance of these early risk characteristics for the later development of psychopathology is being investigated in this sample.
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Recent advances in treating cognitive impairment in schizophrenia
TL;DR: The research into drugs that might enhance cognition in schizophrenia is advancing rapidly, but as yet, no widely applicable, evidence-based treatments are available to the clinician.
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Specificity of developmental precursors to schizophrenia and affective disorders
Peter B. Jones,C. Jane Tarrant +1 more
TL;DR: Birth cohort studies suggest that developmental findings are not specific for schizophrenia, although the magnitude of effects tends to be greater compared with affective disorder.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.