Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Developmental precursors of psychosis.
Matti Isohanni,Irene Isohanni,Hannu Koponen,Johanna Koskinen,Pekka Laine,E. Lauronen,Jouko Miettunen,Pirjo Mäki,Kaisa Riala,Sami Räsänen,Kaisa Saari,Pekka Tienari,Juha Veijola,Graham K. Murray +13 more
TL;DR: No powerful risk factor, premorbid sign, or risk indicator has been identified that is useful for prediction of psychoses in the general population that is not necessarily specific to schizophrenia.
Journal ArticleDOI
The Kraepelinian dichotomy: evidence from developmental and neuroimaging studies.
TL;DR: The Kraepelinian Dichotomy: Evidence from Developmental and Neuroimaging Studies shows clear links to major depressive disorder, particularly in young people aged under the age of 18.
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Is there a degenerative process going on in the brain of people with Schizophrenia
TL;DR: Some ideas about compensatory reactions and Cognitive Reserve Theory is outlined as possible explanations of the recent magnetic resonance imaging studies that show structural changes in the brain after the onset of schizophrenia, at the same time as cognitive functioning does not become more impaired.
Journal ArticleDOI
Core of schizophrenia: estrangement, dementia or neurocognitive disorder?
TL;DR: The empirical morphological and neuropathological evidence does not support any close analogy of schizophrenia with neurodegenerative dementia and the neurodevelopmental model should integrate interactions between emerging psychological structures and genetic and environmental factors.
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Premorbid impairments in early-onset psychosis: differences between patients with schizophrenia and bipolar disorder.
Beatriz Payá,José Manuel Rodríguez-Sánchez,Soraya Otero,Pedro Muñoz,Josefina Castro-Fornieles,Mara Parellada,Ana González-Pinto,Cesar Soutullo,Inmaculada Baeza,Marta Rapado-Castro,Margarita Saenz-Herrero,Dolores Moreno,Celso Arango +12 more
TL;DR: Between childhood and early adolescence, schizophrenia and bipolar patients showed a greater decline in academic adjustment than healthy controls, more specifically in adaptation to school and Intellectual premorbid abnormalities are less specific and probably more linked to early-onset psychosis.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
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Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.