Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Cognitive Impairments in Patients With Schizophrenia Displaying Preserved and Compromised Intellect
Thomas W. Weickert,Terry E. Goldberg,James M. Gold,Llewellen B. Bigelow,Michael F. Egan,Daniel R. Weinberger +5 more
TL;DR: The results suggest that IQ decline, although modal in schizophrenia, is not universally characteristic and that executive function and attention deficits may be core features of schizophrenia, independent of IQ variations.
Journal ArticleDOI
Testing hypotheses on specific environmental causal effects on behavior
TL;DR: In this paper, the authors discuss the need to consider sample selection and the value of longitudinal data in order to test hypotheses on specific environmental risk mechanisms for psychopathology and conclude that environmental risk hypotheses can be put to the test but that it is usually necessary to use a combination of research strategies.
Journal ArticleDOI
Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings.
TL;DR: The most severe impairments are apparent in episodic memory and executive control processes, evident on a background of a generalized cognitive deficit as discussed by the authors, which potentially represent genetic liability to the disorder, as similar, yet milder, impairments were evident in schizophrenia patients even before the onset of psychotic symptoms.
Journal ArticleDOI
Preliminary Findings for Two New Measures of Social and Role Functioning in the Prodromal Phase of Schizophrenia
Barbara A. Cornblatt,Andrea M. Auther,Tara A. Niendam,Christopher W. Smith,Jamie Zinberg,Carrie E. Bearden,Tyrone D. Cannon +6 more
TL;DR: Using 2 new global measures, social functioning was found to be a stable trait, unchanged by treatment, with considerable potential to been a marker of schizophrenia.
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Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study.
Abraham Reichenberg,Avshalom Caspi,HonaLee Harrington,Renate Houts,Richard S.E. Keefe,Robin M. Murray,Richie Poulton,Terrie E. Moffitt +7 more
TL;DR: The findings suggest that the origins of schizophrenia include two interrelated developmental processes evident from childhood to early adolescence (ages 7-13 years).
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.