Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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The Schizophrenia Prodrome Revisited: A Neurodevelopmental Perspective
Barbara A. Cornblatt,Todd Lencz,Christopher W. Smith,Christoph U. Correll,Andrea M. Auther,Emilie Nakayama +5 more
TL;DR: It is concluded that a neurodevelopmental model of schizophrenia is supported by the data and that a range of novel treatment strategies may be neuroprotective by directly affecting the disorder's vulnerability core.
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Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Judith L. Rapoport,Jay N. Giedd,Jonathan D. Blumenthal,Susan D. Hamburger,Neal Jeffries,Thomas V. Fernandez,Rob Nicolson,Jeffrey S. Bedwell,Marge Lenane,Alex P. Zijdenbos,Tomáš Paus,Alan C. Evans +11 more
TL;DR: Patients with very early-onset schizophrenia had both a 4-fold greater decrease in cortical gray matter volume during adolescence and a disease-specific pattern of change.
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Fetal origins of mental health: Evidence and mechanisms
TL;DR: Risk for personality disorders and schizophrenia seems to be linked with fetal growth and adversity, while the evidence for mood disorders is weak and there is evidence that prenatal adversity interacts with genetic and postnatal environmental factors.
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Epidemiology of schizophrenia
H. Häfner,W. an der Heiden +1 more
TL;DR: Among the factors determining social course and outcome are level of social development at onset, the disorder itself, genetic liability, severity of symptoms, and functional deficits, general biological factors, and sex- and age-specific illness behaviour.
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Cognitive deficits as treatment targets in schizophrenia
TL;DR: Evidence is briefly reviewed supporting the idea that the cognitive impairment in schizophrenia is an attractive target for therapeutic intervention and cognitive impairment appears to be a well-defined, reliable and distinct dimension of the illness.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.