Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Predictors of schizophrenia: evidence from the Northern Finland 1966 Birth Cohort and other sources
Matti Isohanni,E. Lauronen,Kristiina Moilanen,Irene Isohanni,Liisa Kemppainen,Hannu Koponen,Jouko Miettunen,Pirjo Mäki,Sami Räsänen,Juha Veijola,Pekka Tienari,Karl-Erik Wahlberg,Graham K. Murray +12 more
TL;DR: No powerful risk factor, premorbid sign or risk indicator has been identified that is useful for the prediction of schizophrenia in the general population.
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Executive function and genetic predisposition to schizophrenia--the Maudsley family study.
P.B.L. Birkett,Thordur Sigmundsson,Tonmoy Sharma,Timothea Toulopoulou,Timothy D. Griffiths,A.M. Reveley,Robin M. Murray +6 more
TL;DR: The results suggest that executive deficits qualitatively similar to those seen in those with schizophrenia reflect familial susceptibility, even taking early IQ and education into consideration, consistent with a genetic mechanism.
Journal ArticleDOI
Early maternal stress and health behaviours and offspring expression of psychosis in adolescence.
TL;DR: It has been suggested that influences operating early in life may affect the risk of postpubertal psychosis outcomes and this hypothesis was tested using a broad outcome of psychotic symptoms expressed in adolescence.
Journal ArticleDOI
The early origins of schizophrenia
TL;DR: Studies of the brain yield results consistent with the multi-system nature of the clinical syndrome of schizophrenia in adult life, and with the notion of a longitudinal or developmental phenotype, of which the adult syndrome is but one aspect.
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Maternal bonding behaviour in schizophrenia and schizoaffective disorder, considering premorbid personality traits
TL;DR: The results suggest that premorbid personality traits should be considered not only in analyses of maternal care behaviour in schizophrenic and schizoaffective patients but also when studying other psychiatric patient groups.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.