Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Journal ArticleDOI
The co-occurrence of nonaffective psychosis and the pervasive developmental disorders: a systematic review.
TL;DR: There is some evidence for elevated rates of comorbid PDD in individuals with childhood-onset psychosis and further work is needed in order to understand the potential mechanisms underlying such co-occurrence and how such affected individuals can be best supported.
Journal ArticleDOI
Influence of cognitive reserve in schizophrenia: A systematic review.
Paula Herrero,Israel Contador,Yaakov Stern,Bernardino Fernández-Calvo,Abraham Sánchez,Francisco Ramos +5 more
TL;DR: People with higher CR may have a lower risk of developing schizophrenia and a later onset of disease, and they present better neuropsychological and functional performance in the illness course.
Book ChapterDOI
Psychosis as an Extreme of Continuous Variation in Dimensions of Psychopathology
TL;DR: Anyone working in clinical psychiatry, especially the psychiatric hospital, is naturally inclined to think that psychosis reveals itself as “cases” in need of treatment, but from the epidemiological perspective, things look somewhat different.
Journal ArticleDOI
White matter integrity, language, and childhood onset schizophrenia.
Kristi A. Clark,Katherine L. Narr,Joseph O'Neill,Jennifer G. Levitt,Prabha Siddarth,Owen R. Phillips,Arthur W. Toga,Rochelle Caplan +7 more
TL;DR: The observed increases in both RD and AD suggest that developmental disturbances affecting the structural connectivity of these pathways are more severe in COS accompanied by severe linguistic impairments.
Journal ArticleDOI
Neuromotor Functioning in Adolescents With Schizotypal Personality Disorder: Associations With Symptoms and Neurocognition
TL;DR: The significant correlations between motor functioning and perseverative responses andnegative symptoms support recent research suggesting that subcortical motor regions play a role in higher order cognition and negative symptoms.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.