Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Developmental Psychotic Risk: Toward a Neurodevelopmentally Informed Staging of Vulnerability to Psychosis.
M. Poletti,Andrea Raballo +1 more
TL;DR: Although mental health services, when they intervene regarding clinical high-risk states, may play a key role in preventing or delaying psychosis, such services detect and follow only a small proportion of individuals who go on to develop psychosis.
Journal Article
Etiología y Signos de Riesgo en la Esquizofrenia
TL;DR: Findings suggest an pathogenetic alteration in the individual’s neurodevelopment that is necessary for the expression of the schizophrenic phenotype.
Cognitive dysfunction in schizophrenia: a familial and genetic approach
TL;DR: Examining the neuropsychological functioning of a representative sample of schizophrenia patients and their family members to estimate the heritability of the cognitive traits and to evaluate the number of their contributing loci aimed at identifying clusters of families with schizophrenia that show convergent cognitive functioning.
Journal ArticleDOI
Schizophrenia: A developmental disorder with a risk of non-specific but avoidable decline
TL;DR: Brain health and cognition can be further impaired by chronic medication effects, cardiovascular and cerebrovascular events, obesity, poor diet, and lack of exercise; drug use, especially of tobacco and cannabis, are likely to contribute.
Journal ArticleDOI
Childhood dyspraxia predicts adult-onset nonaffective-psychosis-spectrum disorder.
Jason Schiffman,Vijay A. Mittal,Emily Kline,Erik Lykke Mortensen,Niels M. Michelsen,Morten Ekstrøm,Zachary B. Millman,Sarnoff A. Mednick,Holger J. Sørensen +8 more
TL;DR: Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of non Affective–Psychosis-Spectrum disorders.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.