Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Can adult anthropometry be used as a 'biomarker' for prenatal and childhood exposures?
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Prepsychotic phase of schizophrenia and related disorders: recent progress and future opportunities
Lisa J. Phillips,Patrick D. McGorry,Alison R. Yung,Thomas H. McGlashan,Barbara A. Cornblatt,Joachim Klosterkötter +5 more
TL;DR: The detection, monitoring and treatment of young people in the prepsychotic phase is a growth area in psychiatry and the ethical considerations about treatment options, treatment of minors and provision of information about risk status must be treated with sensitivity if the potential benefit to many young people and their families is to be realised.
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An examination of hypervigilance for external threat in individuals with generalized anxiety disorder and individuals with persecutory delusions using visual scan paths.
TL;DR: A new measure of hypervigilance was devised and additional support was found for the hypothesis that people with delusions form rapid judgements on the basis of less data-gathering than control groups who are either anxious or have no psychiatric illness.
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Early maternal deprivation retards neurodevelopment in Wistar rats
TL;DR: Investigation of the development of control rats and rats that were exposed to MD on postnatal day 9 shows that early MD delays development, especially of the dopaminergic system and confirms the hypothesis that MD may represent an interesting animal model for the neurodevelopmental hypothesis of schizophrenia.
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Childhood and adolescent predictors of schizophrenia in the Northern Finland 1966 birth cohort--a descriptive life-span model.
Matti Isohanni,Peter B. Jones,Liisa Kemppainen,Tim Croudace,Irene Isohanni,Juha Veijola,Sami Räsänen,Karl-Erik Wahlberg,Pekka Tienari,Paula Rantakallio +9 more
TL;DR: The Northern Finland 1966 Birth Cohort is reviewed to develop a descriptive model of the factors contributing to the development of schizophrenia, with main focus on genetic factors, pregnancy and delivery complications, early development and scholastic performance.
References
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Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.