Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Journal ArticleDOI
Neurodevelopmental and neurodegenerative hypotheses of schizophrenia: A review and critique
TL;DR: The neurodevelopmental and neurodegenerative hypotheses are current general pathophysiological theories relating to schizophrenia and their ability to stimulate scientific inquiry that leads to discovery of the etiology of schizophrenia is examined.
Journal ArticleDOI
Stability and prediction of schizophrenia from adolescence to adulthood
TL;DR: These findings support earlier evidence of schizophrenia being a chronic disorder with high diagnostic stability, and confirm the importance of neurological adversities, delayed language development, and low IQ as factors predictive of schizophrenia.
Book ChapterDOI
A Mentalization-Based Treatment Approach to Disturbances of Social Understanding in Schizophrenia
TL;DR: In this article, the authors presented the rationale for adapting a mentalization-based treatment (MBT) approach to the recovery of mental state understanding in schizophrenia, and proposed a meta-representation-based approach for the treatment of people with schizophrenia.
Book ChapterDOI
The Fetal Origins of Adult Mental Illness
Laura Bennet,Alistair J. Gunn +1 more
TL;DR: This chapter critically examines the hypothesis that the origins of some adult mental illnesses such as schizophrenia derive from adverse events in utero, such as maternal nutrition deficiency, infection and hypoxia, and supports the neurodevelopmental hypothesis.
Book ChapterDOI
Childhood Risk Factors for Adult Schizophrenia in a General Population Birth Cohort at Age 43 Years
TL;DR: Continuities between early factors and adult psychological morbidity have been accepted for considerably longer, and exploration of possible mechanisms for the link has given rise to several explanatory models.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.