Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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BookDOI
The epidemiology of schizophrenia
TL;DR: The implications of epidemiology for service planning in schizophrenia and gene-environment interaction in schizophrenia using neuroimaging are discussed, as well as the relationship between substance abuse and schizophrenia.
Journal ArticleDOI
School performance in Finnish children and later development of schizophrenia: a population-based longitudinal study.
Mary Cannon,Peter B. Jones,Matti O. Huttunen,Antti Tanskanen,Tiia Huttunen,Sophia Rabe-Hesketh,Robin M. Murray +6 more
TL;DR: Poor performance in sports and handicrafts during elementary school, which may indicate a motor coordination deficit, appears to be a risk factor for later schizophrenia.
Journal ArticleDOI
A longitudinal study of neurocognitive function in individuals at-risk for psychosis.
Richard S.E. Keefe,Diana O. Perkins,Hongbin Gu,Robert B. Zipursky,Bruce K. Christensen,J A Lieberman +5 more
TL;DR: In this article, a comprehensive neurocognitive battery and clinical assessments were administered to 37 subjects meeting Criteria of Prodromal States (COPS) criteria for being at risk for psychosis, and two comparison groups: 59 first episode and 47 healthy subjects.
Journal ArticleDOI
In utero infection and adult schizophrenia.
Alan S. Brown,Ezra Susser +1 more
TL;DR: In this article, the authors reviewed emerging evidence indicating that in utero exposure to infection is a risk factor for schizophrenia, and concluded that a prenatal infection increases the liability to schizophrenia in adulthood by adversely affecting the maturation of critical brain structural and functional components implicated in the pathogenesis and pathophysiology of the disorder.
Journal ArticleDOI
Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.
TL;DR: The literature on cognitive deficits across the life span of individuals with psychotic disorder and psychotic-like experiences is reviewed, highlighting the dimensional nature of both psychosis and cognitive ability and identifying premorbid generalized cognitive impairment in schizophrenia that worsens throughout development and stabilizes by the first-episode of psychosis, suggesting a neurodevelopmental course.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.