Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
Reads0
Chats0
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
More filters
Journal ArticleDOI
Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia.
Randal G. Ross,Karen E. Stevens,Karen E. Stevens,William R. Proctor,William R. Proctor,Sherry Leonard,Sherry Leonard,Michael A. Kisley,Sharon K. Hunter,Robert Freedman,Robert Freedman,Catherine E. Adams,Catherine E. Adams +12 more
TL;DR: Review of genetic and neurobiological studies suggests that an early interaction between alpha7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits.
Journal ArticleDOI
Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update
TL;DR: The clinical severity, impact on development, and poor prognosis of childhood-onset schizophrenia may represent a more homogeneous group, and positive symptoms in children are necessary for the diagnosis, and hallucinations are more often multimodal.
Journal ArticleDOI
Sex differences in schizophrenia: A review
TL;DR: In the future it is important to study factors that have been observed in sex differences, heredity, and brain physiology as they relate to schizophrenia to better understand the causes of sex differences in schizophrenia.
Journal ArticleDOI
Childhood inflammatory markers and intelligence as predictors of subsequent persistent depressive symptoms: a longitudinal cohort study.
TL;DR: Lower IQ and higher IL-6 levels in childhood were independently associated with subsequent persistent depressive symptoms in a linear, dose–response fashion, but not with adolescent-onset symptoms.
Journal ArticleDOI
Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta‐analysis
Birgitte Klee Burton,Birgitte Klee Burton,Birgitte Klee Burton,Carsten Hjorthøj,Carsten Hjorthøj,Jens Richardt Møllegaard Jepsen,Jens Richardt Møllegaard Jepsen,Anne Thorup,Anne Thorup,Anne Thorup,Merete Nordentoft,Merete Nordentoft,Merete Nordentoft,Kerstin J. Plessen,Kerstin J. Plessen +14 more
TL;DR: Motor deficits during development likely represent an endophenotype for schizophrenia, although its specificity is limited in relation to other serious mental disorders.
References
More filters
Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.