Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Long-term trajectories of cognitive deficits in schizophrenia: A critical overview
TL;DR: Given the existing controversies on the course of cognitive changes in schizophrenia, differentiated approaches specifically focusing on the peculiarities of the clinical features and changes in specific cognitive domains could shed light on the trajectories of cognitive deficits in schizophrenia and spectrum disorders.
Journal ArticleDOI
A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice
Noboru Hiroi,Hongwen Zhu,Moonsook Lee,Birgit Funke,Makoto Arai,Masanari Itokawa,Raju Kucherlapati,Bernice E. Morrow,Takehito Sawamura,Soh Agatsuma +9 more
TL;DR: The results show that the approximately 200-kb region of 22q11.2 contains a gene(s) responsible for behavioral abnormalities and suggest that distinct genetic components within 22q 11.2 mediate physical and behavioral abnormalities.
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IQ in childhood psychiatric attendees predicts outcome of later schizophrenia at 21 year follow-up.
TL;DR: Preschizophrenic children who merit psychiatric referral are claimed to have a particularly malevolent illness when the psychosis develops later, and the 21-year outcome of a sample of such children was investigated.
Journal ArticleDOI
Behavioral Perturbations After Prenatal Neurogenesis Disturbance in Female Rat
Franck Hazane,Franck Hazane,Marie-Odile Krebs,Marie-Odile Krebs,Thérèse M. Jay,Thérèse M. Jay,Gwenaëlle Le Pen,Gwenaëlle Le Pen +7 more
TL;DR: E17 MAM exposure appears to be a valid model for schizophrenia in both males and females and shows that, in female rat, exposure to MAM at E17 results in a pattern of behavioral changes that mimic positive, negative, and cognitive dimensions of schizophrenia.
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Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings
Dominic Fannon,Lakshika Tennakoon,Alexander Sumich,S. O'Ceallaigh,Victor Doku,Xavier Chitnis,Jennifer K. Lowe,William Soni,Tonmoy Sharma +8 more
TL;DR: Enlargement of both third and lateral ventricles is found in first-episode psychosis and is related to developmental delay in childhood, supporting the view that schizophrenia involves disturbance of neurodevelopmental processes in some patients.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.