Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Birth Weight, Schizophrenia, and Adult Mental Disorder: Is Risk Confined to the Smallest Babies?
Kathryn M. Abel,Susanne Wicks,Ezra Susser,Christina Dalman,Marianne Giørtz Pedersen,Preben Bo Mortensen,Roger T. Webb +6 more
TL;DR: Findings suggest there is an association between birth weight and adult mental disorder, but there is no indication this effect is specific to birth weight less than 2500 g or to schizophrenia.
Journal ArticleDOI
Social predictors of psychotic experiences : specificity and psychological mechanisms.
TL;DR: This article argues that the influence of environment on psychosis can best be understood if the authors focus on specific types of psychotic experiences such as hallucinations and delusions, and that these symptoms are the products of specific cognitive biases and deficits.
Journal ArticleDOI
What causes the onset of psychosis
Matthew R. Broome,James Woolley,Paul Tabraham,Louise Johns,Elvira Bramon,Graham K. Murray,Carmine M. Pariante,Philip McGuire,Robin M. Murray +8 more
TL;DR: It is suggested that genes or developmental damage result in individuals vulnerable to dopamine deregulation, which is often compounded by abuse of drugs such as amphetamines and cannabis, which then propel the individual into a state of dopamine-induced misinterpretation of the environment.
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Unwantedness of a pregnancy and schizophrenia in the child.
TL;DR: The results suggest that unwantedness may operate either directly as a psychosocial stress during development making children more liable to schizophrenia or it may be a marker for behaviours associated with risk in either the mother or the child.
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Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population
Hannah J. Jones,Hannah J. Jones,Evie Stergiakouli,Katherine E. Tansey,Leon Hubbard,Jon Heron,Mary Cannon,Peter Holmans,Glyn Lewis,David Edmund Johannes Linden,Peter B. Jones,George Davey Smith,Michael Conlon O'Donovan,Michael John Owen,James T.R. Walters,Stanley Zammit,Stanley Zammit +16 more
TL;DR: This study demonstrates polygenic overlaps between common genetic polymorphisms associated with schizophrenia and negative symptoms and anxiety disorder but not with psychotic experiences or depression.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.