Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Predictors of schizophrenia--a review.
Pirjo Mäki,Juha Veijola,Peter B. Jones,Graham K. Murray,Hannu Koponen,Pekka Tienari,Jouko Miettunen,Päivikki Tanskanen,Karl-Erik Wahlberg,Johanna Koskinen,E. Lauronen,Matti Isohanni +11 more
TL;DR: In clinical settings, it is helpful to map out possible early risk factors, at least familial risk for psychosis, especially in child, adolescent and young adult mental patients, and in the future predictive models combining data from genetic factors for schizophrenia, antenatalrisk factors, childhood and adolescent development and clinical symptomatology, are helpful.
Journal ArticleDOI
Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients.
Victor Z. Chong,Mia Thompson,Senda Beltaifa,Maree J. Webster,Amanda J. Law,Cynthia Shannon Weickert,Cynthia Shannon Weickert +6 more
TL;DR: This investigation suggests that schizophrenia-associated NRG1 and ErbB4 mRNA elevations also occur at the protein level and may be specific to schizophrenia.
Journal ArticleDOI
Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort
Matti Isohanni,Peter B. Jones,Kristiina Moilanen,Paula Rantakallio,Juha Veijola,Hannu Oja,Markku Koiranen,Jari Jokelainen,Tim Croudace,M-R Jarvelin,M-R Jarvelin +10 more
TL;DR: Hypotheses regarding psychosis as having a developmental dimension with precursors apparent in early life, as well as non-psychotic outcomes, are supported.
Journal ArticleDOI
Neurocognitive profile in 22q11 deletion syndrome and schizophrenia.
Eva W.C. Chow,Eva W.C. Chow,Mark Watson,Donald A. Young,Donald A. Young,Anne S. Bassett,Anne S. Bassett +6 more
TL;DR: In adults with 22qDS, the pattern of neurocognitive differences between those with and without schizophrenia appears similar to that between patients with schizophrenia and controls.
Journal ArticleDOI
Higher Rates of Cigarette Smoking in Male Adolescents Before the Onset of Schizophrenia: A Historical-Prospective Cohort Study
Mark Weiser,Abraham Reichenberg,Itamar Grotto,Ross Yasvitzky,Jonathan Rabinowitz,Gad Lubin,Daniella Nahon,Haim Y. Knobler,Michael H. Davidson +8 more
TL;DR: The prevalence of cigarette smoking among schizophrenia patients is significantly higher than in the general population; this may reflect self-medication of symptoms and/or adverse effects of neuroleptics.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.