Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Journal ArticleDOI
Effect of maternal deprivation on acetylcholinesterase activity and behavioral changes on the ketamine-induced animal model of schizophrenia.
Alexandra I. Zugno,I. M. de Miranda,Josiane Budni,Ana Maria Jesuino Volpato,Renata D. De Luca,Pedro F. Deroza,M. B. de Oliveira,Alexandra S. Heylmann,F. da Rosa Silveira,Patrícia Gomes Wessler,G. Antunes Mastella,Andreza L. Cipriano,João Quevedo +12 more
TL;DR: The results suggest that animals subjected to maternal deprivation had an increased risk for schizophrenia-like behavior and cholinergic alteration.
Journal Article
Primary prevention in psychiatry--adult populations.
TL;DR: Evidence that primary prevention may delay the onset of mental illness and strategies that teach younger individuals to cope with stress and provide psychosocial support have been effective in preventing mood and anxiety disorders.
Journal ArticleDOI
Is there an association between the use of heeled footwear and schizophrenia
TL;DR: Cross-sectional prevalence studies of the association between the use of heeled footwear and schizophrenia should be made in immigrants from regions with a warmer climate or in groups of people who began to wear shoes at different ages.
Book ChapterDOI
Movement Abnormalities: A Putative Biomarker of Risk for Psychosis
Vijay A. Mittal,Elaine F. Walker +1 more
TL;DR: This chapter provides a background for understanding subtypes of movement abnormalities and underlying neurological mechanisms within the context of a neurodevelopmental conceptualization of psychosis and schizophrenia.
Journal ArticleDOI
Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus
D Sinclair,Joseph Cesare,Mary F. McMullen,Greg C. Carlson,Chang-Gyu Hahn,Karin E. Borgmann-Winter +5 more
TL;DR: Sex and DTNBP1 mutation influence the GluN 2B-GluN2A switch at the synapse in a brain-region-specific fashion involving pY1472-GlamN2B, Fyn, and PLCγ, highlighting the possible mechanisms through which risk factors may mediate their effects on vulnerability to disorders of NMDA receptor dysfunction.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.