Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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The 'big bang' theory of the origin of psychosis and the faculty of language.
TL;DR: Language and psychosis have a common origin in the genetic event (the 'big bang') that defined the species.
Journal ArticleDOI
Gyrification abnormalities in childhood- and adolescent-onset schizophrenia.
Tonya White,Nancy C. Andreasen,Nancy C. Andreasen,Nancy C. Andreasen,Peggy Nopoulos,Vincent A. Magnotta +5 more
TL;DR: Children and adolescents with schizophrenia demonstrated patterns of brain morphology that were distinctly different from healthy controls, and these changes may reflect aberrations in cerebral and subcortical connectivity.
Journal ArticleDOI
Social brain, social dysfunction and social withdrawal
Stefano Porcelli,Nic J.A. van der Wee,Steven J.A. van der Werff,Moji Aghajani,Jeffrey C. Glennon,Sabrina van Heukelum,Floriana Mogavero,Antonio Lobo,Francisco Javier Olivera,Elena Lobo,Mar Posadas,Juergen Dukart,Rouba Kozak,Estibaliz Arce,Arfan Ikram,Jacob A. S. Vorstman,Amy C. Bilderbeck,Ilja M.J. Saris,Martien J H Kas,Alessandro Serretti +19 more
TL;DR: Present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders, including schizophrenia, AD, SCZ, and MDD are summarized.
Journal ArticleDOI
The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder
Helen L. Fisher,Peter B. Jones,Paul Fearon,Tom K. J. Craig,Paola Dazzan,Kevin Morgan,Gerard Hutchinson,Gillian A. Doody,Peter McGuffin,Julian Leff,Robin M. Murray,Craig Morgan +11 more
TL;DR: Only specific adverse childhood experiences are associated with psychotic disorders and only in a minority of cases, suggesting that research into the mechanisms underlying the pathway from childhood adversity to psychosis is more fruitful.
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Schizophrenia and the city: A review of literature and prospective study of psychosis and urbanicity in Ireland
Brendan D. Kelly,Brendan D. Kelly,Brendan D. Kelly,Eadbhard O'Callaghan,Eadbhard O'Callaghan,John L. Waddington,Larkin Feeney,Stephen Browne,Paul Scully,Mary Clarke,John F. Quinn,Orflaith McTigue,Maria G. Morgan,Anthony Kinsella,Anthony Kinsella,Conall Larkin +15 more
TL;DR: Results of a prospective study of urbanicity and schizophrenia in Ireland are presented, which provides persuasive evidence that risk for schizophrenia increases with urban birth and/or upbringing, especially among males.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.